Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

Cancer cells adapt to the changing microenvironment by activating different pathways through multiple mechanisms. Here the authors identify long noncoding RNAMIR31HGas a HIF-1α co-activator required for the induction of the hypoxic response and show its oncogenic role in oral carcinogenesis.

Bibliographic Details
Main Authors:	Jing-Wen Shih, Wei-Fan Chiang, Alexander T. H. Wu, Ming-Heng Wu, Ling-Yu Wang, Yen-Ling Yu, Yu-Wen Hung, Wen-Chang Wang, Cheng-Ying Chu, Chiu-Lien Hung, Chun A. Changou, Yun Yen, Hsing-Jien Kung
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15874

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spelling	doaj-ff34e185f1024152aa1e6a455b70c21a2021-05-11T07:46:06ZengNature Publishing GroupNature Communications2041-17232017-06-018111610.1038/ncomms15874Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progressionJing-Wen Shih0Wei-Fan Chiang1Alexander T. H. Wu2Ming-Heng Wu3Ling-Yu Wang4Yen-Ling Yu5Yu-Wen Hung6Wen-Chang Wang7Cheng-Ying Chu8Chiu-Lien Hung9Chun A. Changou10Yun Yen11Hsing-Jien Kung12Ph.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical UniversityDepartment of Oral and Maxillofacial Surgery, Chi-Mei Medical Center, LiouyingPh.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical UniversityPh.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical UniversityDepartment of Biochemistry and Molecular Medicine, Comprehensive Cancer Center, University of California at DavisInstitute of Molecular and Genomic Medicine, National Health Research InstitutesInstitute of Molecular and Genomic Medicine, National Health Research InstitutesPh.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical UniversityResearch Center of Cancer Translational Medicine, Taipei Medical UniversityDepartment of Biochemistry and Molecular Medicine, Comprehensive Cancer Center, University of California at DavisPh.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical UniversityPh.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical UniversityPh.D. Program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical UniversityCancer cells adapt to the changing microenvironment by activating different pathways through multiple mechanisms. Here the authors identify long noncoding RNAMIR31HGas a HIF-1α co-activator required for the induction of the hypoxic response and show its oncogenic role in oral carcinogenesis.https://doi.org/10.1038/ncomms15874
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jing-Wen Shih Wei-Fan Chiang Alexander T. H. Wu Ming-Heng Wu Ling-Yu Wang Yen-Ling Yu Yu-Wen Hung Wen-Chang Wang Cheng-Ying Chu Chiu-Lien Hung Chun A. Changou Yun Yen Hsing-Jien Kung
spellingShingle	Jing-Wen Shih Wei-Fan Chiang Alexander T. H. Wu Ming-Heng Wu Ling-Yu Wang Yen-Ling Yu Yu-Wen Hung Wen-Chang Wang Cheng-Ying Chu Chiu-Lien Hung Chun A. Changou Yun Yen Hsing-Jien Kung Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression Nature Communications
author_facet	Jing-Wen Shih Wei-Fan Chiang Alexander T. H. Wu Ming-Heng Wu Ling-Yu Wang Yen-Ling Yu Yu-Wen Hung Wen-Chang Wang Cheng-Ying Chu Chiu-Lien Hung Chun A. Changou Yun Yen Hsing-Jien Kung
author_sort	Jing-Wen Shih
title	Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression
title_short	Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression
title_full	Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression
title_fullStr	Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression
title_full_unstemmed	Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression
title_sort	long noncoding rna lnchifcar/mir31hg is a hif-1α co-activator driving oral cancer progression
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-06-01
description	Cancer cells adapt to the changing microenvironment by activating different pathways through multiple mechanisms. Here the authors identify long noncoding RNAMIR31HGas a HIF-1α co-activator required for the induction of the hypoxic response and show its oncogenic role in oral carcinogenesis.
url	https://doi.org/10.1038/ncomms15874
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Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression

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