Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine
We assessed the prevalence of Streptococcus pneumoniae serotypes in the nasopharynx of healthy children, antimicrobial susceptibility patterns, risk factors for carriage, and the coverage of heptavalent pneumococcal conjugate vaccine. In 2,799 healthy infants and children, the S. pneumoniae carrier...
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Centers for Disease Control and Prevention
2002-05-01
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doaj-ff3938fc871f4ce3a45243d49d91d1222020-11-25T00:38:18ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592002-05-018547948410.3201/eid0805.010235Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate VaccinePaola MarchisioSusanna EspositoGian Carlo SchitoAnna MarcheseRoberta CavagnaNicola PrincipiWe assessed the prevalence of Streptococcus pneumoniae serotypes in the nasopharynx of healthy children, antimicrobial susceptibility patterns, risk factors for carriage, and the coverage of heptavalent pneumococcal conjugate vaccine. In 2,799 healthy infants and children, the S. pneumoniae carrier rate was 8.6% (serotypes 3, 19F, 23F, 19A, 6B, and 14 were most common). Most pneumococci (69.4%) were resistant to one or more antimicrobial classes. The rate of penicillin resistance was low (9.1%); macrolide resistance was high (52.1%). Overall, 63.2% of the isolates belonged to strains covered by the heptavalent pneumococcal vaccine. This percentage was higher in children <2 years old (73.1%) and in those >2-5 years old(68.9%). Sinusitis in the previous 3 months was the only risk factor for carrier status; acute otitis media was the only risk factor for the carriage of penicillin-resistant S. pneumoniae. Most the isolated strains are covered by the heptavalent conjugate vaccine, especially in the first years of life, suggesting that its use could reduce the incidence of pneumococcal disease.https://wwwnc.cdc.gov/eid/article/8/5/01-0235_articlechildrenconjugate vaccineepidemiologyItalynasopharyngeal carriageStreptococcus pneumoniae |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paola Marchisio Susanna Esposito Gian Carlo Schito Anna Marchese Roberta Cavagna Nicola Principi |
spellingShingle |
Paola Marchisio Susanna Esposito Gian Carlo Schito Anna Marchese Roberta Cavagna Nicola Principi Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine Emerging Infectious Diseases children conjugate vaccine epidemiology Italy nasopharyngeal carriage Streptococcus pneumoniae |
author_facet |
Paola Marchisio Susanna Esposito Gian Carlo Schito Anna Marchese Roberta Cavagna Nicola Principi |
author_sort |
Paola Marchisio |
title |
Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine |
title_short |
Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine |
title_full |
Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine |
title_fullStr |
Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine |
title_full_unstemmed |
Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy Children: Implications for the Use of Heptavalent Pnemococcal Conjugate Vaccine |
title_sort |
nasopharyngeal carriage of streptococcus pneumoniae in healthy children: implications for the use of heptavalent pnemococcal conjugate vaccine |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2002-05-01 |
description |
We assessed the prevalence of Streptococcus pneumoniae serotypes in the nasopharynx of healthy children, antimicrobial susceptibility patterns, risk factors for carriage, and the coverage of heptavalent pneumococcal conjugate vaccine. In 2,799 healthy infants and children, the S. pneumoniae carrier rate was 8.6% (serotypes 3, 19F, 23F, 19A, 6B, and 14 were most common). Most pneumococci (69.4%) were resistant to one or more antimicrobial classes. The rate of penicillin resistance was low (9.1%); macrolide resistance was high (52.1%). Overall, 63.2% of the isolates belonged to strains covered by the heptavalent pneumococcal vaccine. This percentage was higher in children <2 years old (73.1%) and in those >2-5 years old(68.9%). Sinusitis in the previous 3 months was the only risk factor for carrier status; acute otitis media was the only risk factor for the carriage of penicillin-resistant S. pneumoniae. Most the isolated strains are covered by the heptavalent conjugate vaccine, especially in the first years of life, suggesting that its use could reduce the incidence of pneumococcal disease. |
topic |
children conjugate vaccine epidemiology Italy nasopharyngeal carriage Streptococcus pneumoniae |
url |
https://wwwnc.cdc.gov/eid/article/8/5/01-0235_article |
work_keys_str_mv |
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