Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based Approach
Introduction: Metronidazole belongs to the nitroimidazole group of drugs, specifically anti-anaerobic in the nature and has a broad spectrum of activity against protozoa and anaerobic bacteria. Aim: The purpose of this systematic review was to assess the requisite for metronidazole prescription...
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doaj-ff3ce7c8609448bb866b651171b7ee542020-11-25T02:36:29ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2018-12-011212ZE08ZE1110.7860/JCDR/2018/37544.12349Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based ApproachNuvvula Sivakumar0Saha Anupam1Mallineni Sreekanth Kumar2Professor, Department of Paedodontics and Preventive Dentistry, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.Postgraduate Student, Department of Paedodontics and Preventive Dentistry, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.Associate Professor, Department of Paedodontics and Preventive Dentistry, Narayana Dental College and Hospital, Nellore, Andhra Pradesh, India.Introduction: Metronidazole belongs to the nitroimidazole group of drugs, specifically anti-anaerobic in the nature and has a broad spectrum of activity against protozoa and anaerobic bacteria. Aim: The purpose of this systematic review was to assess the requisite for metronidazole prescription among children with pulpal infection either during treatment or postoperatively. Materials and Methods: An electronic literature search was done using databases PubMed, Cochrane Database of Systematic Reviews, OVID and EBSCO Host from January 1991 to December 2015. Hand search were carried outbased on crossreferences, to find additional citations. Articles that met criteria such as randomised clinical trials, cross-sectional studies, invivo human studies were included. Search was confined to English language. The primary outcome was to evaluate the necessity of metronidazole prescription in children with pulpal pathology. Two independent evaluators were involved in the search and kappa statistics were used to evaluate intra & interexaminer reliability. Results: A total of 335 articles were available, among these, only two studies fulfilled established inclusion criteria. These available two studies were cross-sectional studies (Level III). Kappa statistics showed excellent inter and inter-examiner reliability. Conclusion: Although, metronidazole has antibacterial properties against anaerobic microorganisms, there is no clear evidence regarding its prescription among children with pulpal pathology. Further research is required to support or contradict the use of metronidazole prescription in children during or after pulp therapies.https://jcdr.net/articles/PDF/12349/37544_CE[Ra1]_F(SHU)_PF1(A_OM)_PFA(KM)_PN(SL).pdfantibioticsdrug prescriptionnitromidazole grouppulpitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nuvvula Sivakumar Saha Anupam Mallineni Sreekanth Kumar |
spellingShingle |
Nuvvula Sivakumar Saha Anupam Mallineni Sreekanth Kumar Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based Approach Journal of Clinical and Diagnostic Research antibiotics drug prescription nitromidazole group pulpitis |
author_facet |
Nuvvula Sivakumar Saha Anupam Mallineni Sreekanth Kumar |
author_sort |
Nuvvula Sivakumar |
title |
Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based Approach |
title_short |
Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based Approach |
title_full |
Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based Approach |
title_fullStr |
Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based Approach |
title_full_unstemmed |
Prescription of Metronidazole in Paediatric Dentistry-An Evidence Based Approach |
title_sort |
prescription of metronidazole in paediatric dentistry-an evidence based approach |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2018-12-01 |
description |
Introduction: Metronidazole belongs to the nitroimidazole
group of drugs, specifically anti-anaerobic in the nature and has
a broad spectrum of activity against protozoa and anaerobic
bacteria.
Aim: The purpose of this systematic review was to assess the
requisite for metronidazole prescription among children with
pulpal infection either during treatment or postoperatively.
Materials and Methods: An electronic literature search
was done using databases PubMed, Cochrane Database of
Systematic Reviews, OVID and EBSCO Host from January 1991
to December 2015. Hand search were carried outbased on crossreferences, to find additional citations. Articles that met criteria
such as randomised clinical trials, cross-sectional studies, invivo human studies were included. Search was confined to
English language. The primary outcome was to evaluate the
necessity of metronidazole prescription in children with pulpal
pathology. Two independent evaluators were involved in the
search and kappa statistics were used to evaluate intra & interexaminer reliability.
Results: A total of 335 articles were available, among these, only
two studies fulfilled established inclusion criteria. These available
two studies were cross-sectional studies (Level III). Kappa
statistics showed excellent inter and inter-examiner reliability.
Conclusion: Although, metronidazole has antibacterial
properties against anaerobic microorganisms, there is no clear
evidence regarding its prescription among children with pulpal
pathology. Further research is required to support or contradict
the use of metronidazole prescription in children during or after
pulp therapies. |
topic |
antibiotics drug prescription nitromidazole group pulpitis |
url |
https://jcdr.net/articles/PDF/12349/37544_CE[Ra1]_F(SHU)_PF1(A_OM)_PFA(KM)_PN(SL).pdf |
work_keys_str_mv |
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