Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care Hospital
Introduction: Fungi are being increasingly implicated in the aetiopathology of Chronic Rhinosinusitis (CRS). Fungal Rhinosinusitis (FRS) is frequently seen in diabetic or immunocompromised patients, although it has also been reported in immunocompetent individuals. The spectrum of fungal involvement...
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doaj-ff4b62c1ee9c4a27a0e665fd8f61368b2021-01-15T09:16:32ZengJCDR Research and Publications Pvt. Ltd.National Journal of Laboratory Medicine2277-85512455-68822020-10-0194010410.7860/NJLM/2020/45042:2412Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care HospitalBichitrananda Swain0 Swati Jain1Sunita Kabi2Associate Professor, Department of Microbiology, SLN Medical College and Hospital, Koraput, Odisha, IndiaAssistant Professor, Department of Microbiology, IMS and SUM Hospital, S"O"A University, Bhubaneswar, Odisha, India. Assistant Professor, Department of Microbiology, IMS and SUM Hospital, S"O"A University, Bhubaneswar, Odisha, IndiaIntroduction: Fungi are being increasingly implicated in the aetiopathology of Chronic Rhinosinusitis (CRS). Fungal Rhinosinusitis (FRS) is frequently seen in diabetic or immunocompromised patients, although it has also been reported in immunocompetent individuals. The spectrum of fungal involvement runs from benign colonisation to potentially life-threatening invasive disease. There are only a few landmark studies from India on FRS. Aim: To determine the prevalence of FRS and to analyse its clinicomycological profile. Materials and Methods: Thirty-nine patients with clinical suspicion of CRS during a period of one year were included in this prospective study. The sinonasal specimens were subjected to microscopy by potassium hydroxide (KOH) mount followed by fungal culture as per standard mycological technique. Specimens were also subjected to Histopathological Examination (HPE). The obtained data from the study was analysed by chi-square test using Statistical Package for the Social Sciences (SPSS) software. Results: The prevalence of FRS in this study was 41% (n=16) with a higher prevalence among third and fourth decades (n=10, 62.5%) of life, with a female predominance (n=11, 68.75%). Aspergillus spp. was the most prevalent organism (n=6) with A. flavus (4/6) being the commonest species. Allergic FRS (43.75%) was the most common presentation. The prevalence was higher among individuals who were immunocompetent (11/16). Conclusion: As FRS varies in presentation, perfect mycological identification plays a crucial role in diagnosing chronic sinusitis and also provides therapeutic guidance for the treatment of infection with unusual agents. http://www.njlm.net/articles/PDF/2412/45042_CE[Ra1]_F(RK)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU)_PF2(AvG_OM).pdfallergic fungal rhinosinusitisaspergillus flavuschronic rhinosinusitisinvasive fungal infections |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bichitrananda Swain Swati Jain Sunita Kabi |
spellingShingle |
Bichitrananda Swain Swati Jain Sunita Kabi Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care Hospital National Journal of Laboratory Medicine allergic fungal rhinosinusitis aspergillus flavus chronic rhinosinusitis invasive fungal infections |
author_facet |
Bichitrananda Swain Swati Jain Sunita Kabi |
author_sort |
Bichitrananda Swain |
title |
Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care Hospital |
title_short |
Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care Hospital |
title_full |
Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care Hospital |
title_fullStr |
Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care Hospital |
title_full_unstemmed |
Prevalence and Clinicomycological Profile of Fungal Rhinosinusitis in a Tertiary Care Hospital |
title_sort |
prevalence and clinicomycological profile of fungal rhinosinusitis in a tertiary care hospital |
publisher |
JCDR Research and Publications Pvt. Ltd. |
series |
National Journal of Laboratory Medicine |
issn |
2277-8551 2455-6882 |
publishDate |
2020-10-01 |
description |
Introduction: Fungi are being increasingly implicated in the aetiopathology of Chronic Rhinosinusitis (CRS). Fungal Rhinosinusitis (FRS) is frequently seen in diabetic or immunocompromised patients, although it has also been reported in immunocompetent individuals. The spectrum of fungal involvement runs from benign colonisation to potentially life-threatening invasive disease. There are only a few landmark studies from India on FRS.
Aim: To determine the prevalence of FRS and to analyse its clinicomycological profile.
Materials and Methods: Thirty-nine patients with clinical suspicion of CRS during a period of one year were included in this prospective study. The sinonasal specimens were subjected to microscopy by potassium hydroxide (KOH) mount followed by fungal culture as per standard mycological technique. Specimens were also subjected to Histopathological Examination (HPE). The obtained data from the study was analysed by chi-square test using Statistical Package for the Social Sciences (SPSS) software.
Results: The prevalence of FRS in this study was 41% (n=16) with a higher prevalence among third and fourth decades (n=10, 62.5%) of life, with a female predominance (n=11, 68.75%). Aspergillus spp. was the most prevalent organism (n=6) with A. flavus (4/6) being the commonest species. Allergic FRS (43.75%) was the most common presentation. The prevalence was higher among individuals who were immunocompetent (11/16).
Conclusion: As FRS varies in presentation, perfect mycological identification plays a crucial role in diagnosing chronic sinusitis and also provides therapeutic guidance for the treatment of infection with unusual agents.
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topic |
allergic fungal rhinosinusitis aspergillus flavus chronic rhinosinusitis invasive fungal infections |
url |
http://www.njlm.net/articles/PDF/2412/45042_CE[Ra1]_F(RK)_PF1(AG_SHU)_PFA(SHU)_PB(AG_SHU)_PN(SHU)_PF2(AvG_OM).pdf |
work_keys_str_mv |
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