Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily perm...
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Series: | Journal of Nanomaterials |
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doaj-ff5070b910e74341a574326854ebe3252020-11-24T22:57:46ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292017-01-01201710.1155/2017/78592897859289Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance ImagingDavid Kovář0Aneta Malá1Jitka Mlčochová2Michal Kalina3Zdenka Fohlerová4Antonín Hlaváček5Zdeněk Farka6Petr Skládal7Zenon Starčuk8Radovan Jiřík9Ondřej Slabý10Jaromír Hubálek11Central European Institute of Technology, Masaryk University, Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicMaterials Research Centre, Faculty of Chemistry, Brno University of Technology, Brno, Czech RepublicCentral European Institute of Technology, Brno University of Technology, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicCentral European Institute of Technology, Brno University of Technology, Brno, Czech RepublicMagnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.http://dx.doi.org/10.1155/2017/7859289 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
David Kovář Aneta Malá Jitka Mlčochová Michal Kalina Zdenka Fohlerová Antonín Hlaváček Zdeněk Farka Petr Skládal Zenon Starčuk Radovan Jiřík Ondřej Slabý Jaromír Hubálek |
spellingShingle |
David Kovář Aneta Malá Jitka Mlčochová Michal Kalina Zdenka Fohlerová Antonín Hlaváček Zdeněk Farka Petr Skládal Zenon Starčuk Radovan Jiřík Ondřej Slabý Jaromír Hubálek Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging Journal of Nanomaterials |
author_facet |
David Kovář Aneta Malá Jitka Mlčochová Michal Kalina Zdenka Fohlerová Antonín Hlaváček Zdeněk Farka Petr Skládal Zenon Starčuk Radovan Jiřík Ondřej Slabý Jaromír Hubálek |
author_sort |
David Kovář |
title |
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging |
title_short |
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging |
title_full |
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging |
title_fullStr |
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging |
title_full_unstemmed |
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging |
title_sort |
preparation and characterisation of highly stable iron oxide nanoparticles for magnetic resonance imaging |
publisher |
Hindawi Limited |
series |
Journal of Nanomaterials |
issn |
1687-4110 1687-4129 |
publishDate |
2017-01-01 |
description |
Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe. |
url |
http://dx.doi.org/10.1155/2017/7859289 |
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