Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging

Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily perm...

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Main Authors: David Kovář, Aneta Malá, Jitka Mlčochová, Michal Kalina, Zdenka Fohlerová, Antonín Hlaváček, Zdeněk Farka, Petr Skládal, Zenon Starčuk, Radovan Jiřík, Ondřej Slabý, Jaromír Hubálek
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2017/7859289
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spelling doaj-ff5070b910e74341a574326854ebe3252020-11-24T22:57:46ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292017-01-01201710.1155/2017/78592897859289Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance ImagingDavid Kovář0Aneta Malá1Jitka Mlčochová2Michal Kalina3Zdenka Fohlerová4Antonín Hlaváček5Zdeněk Farka6Petr Skládal7Zenon Starčuk8Radovan Jiřík9Ondřej Slabý10Jaromír Hubálek11Central European Institute of Technology, Masaryk University, Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicMaterials Research Centre, Faculty of Chemistry, Brno University of Technology, Brno, Czech RepublicCentral European Institute of Technology, Brno University of Technology, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech RepublicInstitute of Scientific Instruments of the Czech Academy of Sciences, Brno, Czech RepublicCentral European Institute of Technology, Masaryk University, Brno, Czech RepublicCentral European Institute of Technology, Brno University of Technology, Brno, Czech RepublicMagnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.http://dx.doi.org/10.1155/2017/7859289
collection DOAJ
language English
format Article
sources DOAJ
author David Kovář
Aneta Malá
Jitka Mlčochová
Michal Kalina
Zdenka Fohlerová
Antonín Hlaváček
Zdeněk Farka
Petr Skládal
Zenon Starčuk
Radovan Jiřík
Ondřej Slabý
Jaromír Hubálek
spellingShingle David Kovář
Aneta Malá
Jitka Mlčochová
Michal Kalina
Zdenka Fohlerová
Antonín Hlaváček
Zdeněk Farka
Petr Skládal
Zenon Starčuk
Radovan Jiřík
Ondřej Slabý
Jaromír Hubálek
Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
Journal of Nanomaterials
author_facet David Kovář
Aneta Malá
Jitka Mlčochová
Michal Kalina
Zdenka Fohlerová
Antonín Hlaváček
Zdeněk Farka
Petr Skládal
Zenon Starčuk
Radovan Jiřík
Ondřej Slabý
Jaromír Hubálek
author_sort David Kovář
title Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
title_short Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
title_full Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
title_fullStr Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
title_full_unstemmed Preparation and Characterisation of Highly Stable Iron Oxide Nanoparticles for Magnetic Resonance Imaging
title_sort preparation and characterisation of highly stable iron oxide nanoparticles for magnetic resonance imaging
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2017-01-01
description Magnetic nanoparticles produced using aqueous coprecipitation usually exhibit wide particle size distribution. Synthesis of small and uniform magnetic nanoparticles has been the subject of extensive research over recent years. Sufficiently small superparamagnetic iron oxide nanoparticles easily permeate tissues and may enhance the contrast in magnetic resonance imaging. Furthermore, their unique small size also allows them to migrate into cells and other body compartments. To better control their synthesis, a chemical coprecipitation protocol was carefully optimised regarding the influence of the injection rate of base and incubation times. The citrate-stabilised particles were produced with a narrow average size range below 2 nm and excellent stability. The stability of nanoparticles was monitored by long-term measurement of zeta potentials and relaxivity. Biocompatibility was tested on the Caki-2 cells with good tolerance. The application of nanoparticles for magnetic resonance imaging (MRI) was then evaluated. The relaxivities (r1,r2) and r2/r1 ratio calculated from MR images of prepared phantoms indicate the nanoparticles as a promising T2-contrast probe.
url http://dx.doi.org/10.1155/2017/7859289
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