Influence of NaCl on the Structure and Dynamics of Phospholipid Layers

We present a structural and dynamical analysis of the influence of NaCl on multilayer stacks of phospholipids on a solid surface. To this end, multilayer stacks of phospholipids (L-α-phosphatidylcholine, abbreviated as SoyPC) are investigated with neutron reflectometry, grazing-incidence small-angle...

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Bibliographic Details
Main Authors: Sebastian Jaksch, Olaf Holderer, Henrich Frielinghaus, Alexandros Koutsioubas, Piotr Zolnierczuk, Dominic William Hayward, Stephan Förster, Peter Müller-Buschbaum
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physics
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Online Access:https://www.frontiersin.org/articles/10.3389/fphy.2021.628219/full
Description
Summary:We present a structural and dynamical analysis of the influence of NaCl on multilayer stacks of phospholipids on a solid surface. To this end, multilayer stacks of phospholipids (L-α-phosphatidylcholine, abbreviated as SoyPC) are investigated with neutron reflectometry, grazing-incidence small-angle neutron scattering (GISANS) and grazing-incidence neutron-spin echo spectroscopy (GINSES). We show both that the NaCl influence on the structure is predominantly on water-head group interface and also, that the change in dynamics is restricted to an associated change in the inter-plane viscosity. Using this knowledge, it is possible to model the dynamical behavior of a phospholipid membrane in response to a salt concentration of the solvent using only a single parameter, namely the in-plane viscosity. The excellent agreement with our previously published model also strongly supports the existence of a thermally excited surface mode in phospholipid membranes for close-to-physiological conditions.
ISSN:2296-424X