Lacrimal Gland Amyloidosis in an Elderly Patient

• Main Authors: Toshiya Nagai, Tatsuya Yunoki, Atsushi Hayashi
• Format: Article
• Language: English
• Published: Karger Publishers 2020-03-01
• Series: Case Reports in Ophthalmology
• Subjects: lacrimal gland; localized amyloidosis; transthyretin
• Online Access: https://www.karger.com/Article/FullText/505480

Localized amyloidosis of the lacrimal gland is a rare disease. We report a case of transthyretin-positive localized amyloidosis of the lacrimal gland in a 74-year-old man with left lacrimal gland swelling. Biopsy of the left lacrimal gland showed extensive deposition of nonstructural eosinophilic material in the secretory gland and ducts, which stained positive with direct fast scarlet. Immunostaining was negative for amyloid A and positive for both globulin light chain (kappa, lambda) and transthyretin. It is necessary to consider the possibility of senile systemic amyloidosis, even if localized amyloidosis of the lacrimal gland is suspected.