Lacrimal Gland Amyloidosis in an Elderly Patient

Localized amyloidosis of the lacrimal gland is a rare disease. We report a case of transthyretin-positive localized amyloidosis of the lacrimal gland in a 74-year-old man with left lacrimal gland swelling. Biopsy of the left lacrimal gland showed extensive deposition of nonstructural eosinophilic ma...

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Main Authors: Toshiya Nagai, Tatsuya Yunoki, Atsushi Hayashi
Format: Article
Language:English
Published: Karger Publishers 2020-03-01
Series:Case Reports in Ophthalmology
Subjects:
Online Access:https://www.karger.com/Article/FullText/505480
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spelling doaj-ff59cdf6e1f04670912a3efa6dde13ce2020-11-25T02:56:51ZengKarger PublishersCase Reports in Ophthalmology1663-26992020-03-0111110010510.1159/000505480505480Lacrimal Gland Amyloidosis in an Elderly PatientToshiya NagaiTatsuya YunokiAtsushi HayashiLocalized amyloidosis of the lacrimal gland is a rare disease. We report a case of transthyretin-positive localized amyloidosis of the lacrimal gland in a 74-year-old man with left lacrimal gland swelling. Biopsy of the left lacrimal gland showed extensive deposition of nonstructural eosinophilic material in the secretory gland and ducts, which stained positive with direct fast scarlet. Immunostaining was negative for amyloid A and positive for both globulin light chain (kappa, lambda) and transthyretin. It is necessary to consider the possibility of senile systemic amyloidosis, even if localized amyloidosis of the lacrimal gland is suspected.https://www.karger.com/Article/FullText/505480lacrimal glandlocalized amyloidosistransthyretin
collection DOAJ
language English
format Article
sources DOAJ
author Toshiya Nagai
Tatsuya Yunoki
Atsushi Hayashi
spellingShingle Toshiya Nagai
Tatsuya Yunoki
Atsushi Hayashi
Lacrimal Gland Amyloidosis in an Elderly Patient
Case Reports in Ophthalmology
lacrimal gland
localized amyloidosis
transthyretin
author_facet Toshiya Nagai
Tatsuya Yunoki
Atsushi Hayashi
author_sort Toshiya Nagai
title Lacrimal Gland Amyloidosis in an Elderly Patient
title_short Lacrimal Gland Amyloidosis in an Elderly Patient
title_full Lacrimal Gland Amyloidosis in an Elderly Patient
title_fullStr Lacrimal Gland Amyloidosis in an Elderly Patient
title_full_unstemmed Lacrimal Gland Amyloidosis in an Elderly Patient
title_sort lacrimal gland amyloidosis in an elderly patient
publisher Karger Publishers
series Case Reports in Ophthalmology
issn 1663-2699
publishDate 2020-03-01
description Localized amyloidosis of the lacrimal gland is a rare disease. We report a case of transthyretin-positive localized amyloidosis of the lacrimal gland in a 74-year-old man with left lacrimal gland swelling. Biopsy of the left lacrimal gland showed extensive deposition of nonstructural eosinophilic material in the secretory gland and ducts, which stained positive with direct fast scarlet. Immunostaining was negative for amyloid A and positive for both globulin light chain (kappa, lambda) and transthyretin. It is necessary to consider the possibility of senile systemic amyloidosis, even if localized amyloidosis of the lacrimal gland is suspected.
topic lacrimal gland
localized amyloidosis
transthyretin
url https://www.karger.com/Article/FullText/505480
work_keys_str_mv AT toshiyanagai lacrimalglandamyloidosisinanelderlypatient
AT tatsuyayunoki lacrimalglandamyloidosisinanelderlypatient
AT atsushihayashi lacrimalglandamyloidosisinanelderlypatient
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