Lacrimal Gland Amyloidosis in an Elderly Patient
Localized amyloidosis of the lacrimal gland is a rare disease. We report a case of transthyretin-positive localized amyloidosis of the lacrimal gland in a 74-year-old man with left lacrimal gland swelling. Biopsy of the left lacrimal gland showed extensive deposition of nonstructural eosinophilic ma...
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doaj-ff59cdf6e1f04670912a3efa6dde13ce2020-11-25T02:56:51ZengKarger PublishersCase Reports in Ophthalmology1663-26992020-03-0111110010510.1159/000505480505480Lacrimal Gland Amyloidosis in an Elderly PatientToshiya NagaiTatsuya YunokiAtsushi HayashiLocalized amyloidosis of the lacrimal gland is a rare disease. We report a case of transthyretin-positive localized amyloidosis of the lacrimal gland in a 74-year-old man with left lacrimal gland swelling. Biopsy of the left lacrimal gland showed extensive deposition of nonstructural eosinophilic material in the secretory gland and ducts, which stained positive with direct fast scarlet. Immunostaining was negative for amyloid A and positive for both globulin light chain (kappa, lambda) and transthyretin. It is necessary to consider the possibility of senile systemic amyloidosis, even if localized amyloidosis of the lacrimal gland is suspected.https://www.karger.com/Article/FullText/505480lacrimal glandlocalized amyloidosistransthyretin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Toshiya Nagai Tatsuya Yunoki Atsushi Hayashi |
spellingShingle |
Toshiya Nagai Tatsuya Yunoki Atsushi Hayashi Lacrimal Gland Amyloidosis in an Elderly Patient Case Reports in Ophthalmology lacrimal gland localized amyloidosis transthyretin |
author_facet |
Toshiya Nagai Tatsuya Yunoki Atsushi Hayashi |
author_sort |
Toshiya Nagai |
title |
Lacrimal Gland Amyloidosis in an Elderly Patient |
title_short |
Lacrimal Gland Amyloidosis in an Elderly Patient |
title_full |
Lacrimal Gland Amyloidosis in an Elderly Patient |
title_fullStr |
Lacrimal Gland Amyloidosis in an Elderly Patient |
title_full_unstemmed |
Lacrimal Gland Amyloidosis in an Elderly Patient |
title_sort |
lacrimal gland amyloidosis in an elderly patient |
publisher |
Karger Publishers |
series |
Case Reports in Ophthalmology |
issn |
1663-2699 |
publishDate |
2020-03-01 |
description |
Localized amyloidosis of the lacrimal gland is a rare disease. We report a case of transthyretin-positive localized amyloidosis of the lacrimal gland in a 74-year-old man with left lacrimal gland swelling. Biopsy of the left lacrimal gland showed extensive deposition of nonstructural eosinophilic material in the secretory gland and ducts, which stained positive with direct fast scarlet. Immunostaining was negative for amyloid A and positive for both globulin light chain (kappa, lambda) and transthyretin. It is necessary to consider the possibility of senile systemic amyloidosis, even if localized amyloidosis of the lacrimal gland is suspected. |
topic |
lacrimal gland localized amyloidosis transthyretin |
url |
https://www.karger.com/Article/FullText/505480 |
work_keys_str_mv |
AT toshiyanagai lacrimalglandamyloidosisinanelderlypatient AT tatsuyayunoki lacrimalglandamyloidosisinanelderlypatient AT atsushihayashi lacrimalglandamyloidosisinanelderlypatient |
_version_ |
1724711991559323648 |