Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks
A minimal cut set is a minimal set of reactions whose inactivation would guarantee a failure in a certain network function or functions. Minimal cut sets (MCSs) were initially developed from the metabolic pathway analysis method (MPA) of elementary modes (EMs); they provide a way of identifying targ...
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doaj-ff669d6f5caa48d7b0f4382edf0397cf2020-11-25T01:44:22ZengMDPI AGMetabolites2218-19892012-09-012356759510.3390/metabo2030567Minimal Cut Sets and the Use of Failure Modes in Metabolic NetworksSangaalofa T. ClarkWynand S. VerwoerdA minimal cut set is a minimal set of reactions whose inactivation would guarantee a failure in a certain network function or functions. Minimal cut sets (MCSs) were initially developed from the metabolic pathway analysis method (MPA) of elementary modes (EMs); they provide a way of identifying target genes for eliminating a certain objective function from a holistic perspective that takes into account the structure of the whole metabolic network. The concept of MCSs is fairly new and still being explored and developed; the initial concept has developed into a generalized form and its similarity to other network characterizations are discussed. MCSs can be used in conjunction with other constraints-based methods to get a better understanding of the capability of metabolic networks and the interrelationship between metabolites and enzymes/genes. The concept could play an important role in systems biology by contributing to fields such as metabolic and genetic engineering where it could assist in finding ways of producing industrially relevant compounds from renewable resources, not only for economical, but also for sustainability, reasons.http://www.mdpi.com/2218-1989/2/3/567minimal cut setselementary modesmetabolic networks |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sangaalofa T. Clark Wynand S. Verwoerd |
spellingShingle |
Sangaalofa T. Clark Wynand S. Verwoerd Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks Metabolites minimal cut sets elementary modes metabolic networks |
author_facet |
Sangaalofa T. Clark Wynand S. Verwoerd |
author_sort |
Sangaalofa T. Clark |
title |
Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks |
title_short |
Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks |
title_full |
Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks |
title_fullStr |
Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks |
title_full_unstemmed |
Minimal Cut Sets and the Use of Failure Modes in Metabolic Networks |
title_sort |
minimal cut sets and the use of failure modes in metabolic networks |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2012-09-01 |
description |
A minimal cut set is a minimal set of reactions whose inactivation would guarantee a failure in a certain network function or functions. Minimal cut sets (MCSs) were initially developed from the metabolic pathway analysis method (MPA) of elementary modes (EMs); they provide a way of identifying target genes for eliminating a certain objective function from a holistic perspective that takes into account the structure of the whole metabolic network. The concept of MCSs is fairly new and still being explored and developed; the initial concept has developed into a generalized form and its similarity to other network characterizations are discussed. MCSs can be used in conjunction with other constraints-based methods to get a better understanding of the capability of metabolic networks and the interrelationship between metabolites and enzymes/genes. The concept could play an important role in systems biology by contributing to fields such as metabolic and genetic engineering where it could assist in finding ways of producing industrially relevant compounds from renewable resources, not only for economical, but also for sustainability, reasons. |
topic |
minimal cut sets elementary modes metabolic networks |
url |
http://www.mdpi.com/2218-1989/2/3/567 |
work_keys_str_mv |
AT sangaalofatclark minimalcutsetsandtheuseoffailuremodesinmetabolicnetworks AT wynandsverwoerd minimalcutsetsandtheuseoffailuremodesinmetabolicnetworks |
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