Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study
Objective: Early identification of individuals at high risk for metabolic derangements after an attack of acute pancreatitis (AP) is critical with a view to tertiary preventing of this disease. The aim was to investigate whether fasting pancreatic and gut hormones at baseline were predictive of futu...
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Bioscientifica
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doaj-ff6c377ec42342569088e39a0722b8c42021-07-02T04:54:25ZengBioscientificaEndocrine Connections2049-36142049-36142021-07-01107715724https://doi.org/10.1530/EC-21-0229Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort studySakina H Bharmal0Wandia Kimita1Juyeon Ko2Maxim S Petrov3School of Medicine, University of Auckland, Auckland, New ZealandSchool of Medicine, University of Auckland, Auckland, New ZealandSchool of Medicine, University of Auckland, Auckland, New ZealandSchool of Medicine, University of Auckland, Auckland, New ZealandObjective: Early identification of individuals at high risk for metabolic derangements after an attack of acute pancreatitis (AP) is critical with a view to tertiary preventing of this disease. The aim was to investigate whether fasting pancreatic and gut hormones at baseline were predictive of future risk of new-onset prediabete s after acute pancreatitis (NOPAP) in individuals with non-necrotising AP. Methods: This was a prospective longitudinal cohort study that included 69 consecutive non-diabetic participants with AP, of whom 55% (n = 38) had normoglycaemia both at baseline and during follow-up, 25% (n = 17) had prediabetes both at baseline and during follow-up, and 20% (n = 14) were normoglycaemic at baseline but developed NOPAP during follow-up. The associations between the study groups and circulating fasting levels of pancreatic and gut hormones (insulin, glucagon, C-peptide, amylin, glucose-dependent insulinotropic peptide, glucagon-like peptide-1, pancreatic polypeptide, and peptide YY) were studied using multinomial regression in both unadjusted and adjusted analyses. Results: Elevated plasma insulin and glucagon at baseline were significa ntly associated with NOPAP (adjusted odds ratio 1.99, 95% CI 1.01 to 3.92 and a djusted odds ratio 3.44, 95% CI 1.06 to 11.19, respectively). The same hormones had no s ignificant association with antecedent prediabetes in AP. The other studied hormones w ere not significantly associated with the study groups. Conclusions: Normoglycaemic AP individuals with elevated fasting levels of insulin and glucagon at baseline constitute a high-risk group for future NO PAP. https://ec.bioscientifica.com/view/journals/ec/10/7/EC-21-0229.xmlpancreatitisinsulinglucagonnew-onset prediabetespredictionprospective cohort study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sakina H Bharmal Wandia Kimita Juyeon Ko Maxim S Petrov |
spellingShingle |
Sakina H Bharmal Wandia Kimita Juyeon Ko Maxim S Petrov Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study Endocrine Connections pancreatitis insulin glucagon new-onset prediabetes prediction prospective cohort study |
author_facet |
Sakina H Bharmal Wandia Kimita Juyeon Ko Maxim S Petrov |
author_sort |
Sakina H Bharmal |
title |
Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study |
title_short |
Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study |
title_full |
Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study |
title_fullStr |
Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study |
title_full_unstemmed |
Pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study |
title_sort |
pancreatic and gut hormones as predictors of new-onset prediabetes after non-necrotising acute pancreatitis: a prospective longitudinal cohort study |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2021-07-01 |
description |
Objective: Early identification of individuals at high risk for metabolic derangements after an attack of acute pancreatitis (AP) is critical with a view to tertiary preventing of this disease. The aim was to investigate whether fasting pancreatic and gut hormones at baseline were predictive of future risk of new-onset prediabete s after acute pancreatitis (NOPAP) in individuals with non-necrotising AP.
Methods: This was a prospective longitudinal cohort study that included 69 consecutive non-diabetic participants with AP, of whom 55% (n = 38) had normoglycaemia both at baseline and during follow-up, 25% (n = 17) had prediabetes both at baseline and during follow-up, and 20% (n = 14) were normoglycaemic at baseline but developed NOPAP during follow-up. The associations between the study groups and circulating fasting levels of pancreatic and gut hormones (insulin, glucagon, C-peptide, amylin, glucose-dependent insulinotropic peptide, glucagon-like peptide-1, pancreatic polypeptide, and peptide YY) were studied using multinomial regression in both unadjusted and adjusted analyses.
Results: Elevated plasma insulin and glucagon at baseline were significa ntly associated with NOPAP (adjusted odds ratio 1.99, 95% CI 1.01 to 3.92 and a djusted odds ratio 3.44, 95% CI 1.06 to 11.19, respectively). The same hormones had no s ignificant association with antecedent prediabetes in AP. The other studied hormones w ere not significantly associated with the study groups.
Conclusions: Normoglycaemic AP individuals with elevated fasting levels of insulin and glucagon at baseline constitute a high-risk group for future NO PAP.
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topic |
pancreatitis insulin glucagon new-onset prediabetes prediction prospective cohort study |
url |
https://ec.bioscientifica.com/view/journals/ec/10/7/EC-21-0229.xml |
work_keys_str_mv |
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