The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine
Circadian clocks evolved to allow plants and animals to adapt their behaviors to the 24-hr change in the external environment due to the Earth's rotation. While the first scientific observation of circadian rhythm in the plant leaf movement may be dated back to the early 18th century, it took 2...
Main Author: | |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2018-02-01
|
Series: | Biomedical Journal |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417018300179 |
id |
doaj-ff865067443e478ba7acadc3aef542ee |
---|---|
record_format |
Article |
spelling |
doaj-ff865067443e478ba7acadc3aef542ee2021-02-02T05:02:19ZengElsevierBiomedical Journal2319-41702018-02-0141158The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or MedicineRong-Chi Huang0Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Healthy Aging Research Center, Chang Gung University, Taoyuan, Taiwan; Neuroscience Research Center, Chang Gung Memorial Hospital, Linkou, Taiwan; Corresponding author. Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, 259 Wenhua 1st Rd., Gueishan, Taoyuan, 33305, Taiwan.Circadian clocks evolved to allow plants and animals to adapt their behaviors to the 24-hr change in the external environment due to the Earth's rotation. While the first scientific observation of circadian rhythm in the plant leaf movement may be dated back to the early 18th century, it took 200 years to realize that the leaf movement is controlled by an endogenous circadian clock. The cloning and characterization of the first Drosophila clock gene period in the early 1980s, independently by Jeffery C. Hall and Michael Rosbash at Brandeis University and Michael Young at Rockefeller University, paved the way for their further discoveries of additional genes and proteins, culminating in establishing the so-called transcriptional translational feedback loop (TTFL) model for the generation of autonomous oscillator with a period of ∼24 h. The 2017 Nobel Prize in Physiology or Medicine was awarded to honor their discoveries of molecular mechanisms controlling the circadian rhythm. Keywords: Circadian clocks, Circadian rhythms, Clock genes, TTFL model, 2017 Nobel Prizehttp://www.sciencedirect.com/science/article/pii/S2319417018300179 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rong-Chi Huang |
spellingShingle |
Rong-Chi Huang The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine Biomedical Journal |
author_facet |
Rong-Chi Huang |
author_sort |
Rong-Chi Huang |
title |
The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine |
title_short |
The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine |
title_full |
The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine |
title_fullStr |
The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine |
title_full_unstemmed |
The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine |
title_sort |
discoveries of molecular mechanisms for the circadian rhythm: the 2017 nobel prize in physiology or medicine |
publisher |
Elsevier |
series |
Biomedical Journal |
issn |
2319-4170 |
publishDate |
2018-02-01 |
description |
Circadian clocks evolved to allow plants and animals to adapt their behaviors to the 24-hr change in the external environment due to the Earth's rotation. While the first scientific observation of circadian rhythm in the plant leaf movement may be dated back to the early 18th century, it took 200 years to realize that the leaf movement is controlled by an endogenous circadian clock. The cloning and characterization of the first Drosophila clock gene period in the early 1980s, independently by Jeffery C. Hall and Michael Rosbash at Brandeis University and Michael Young at Rockefeller University, paved the way for their further discoveries of additional genes and proteins, culminating in establishing the so-called transcriptional translational feedback loop (TTFL) model for the generation of autonomous oscillator with a period of ∼24 h. The 2017 Nobel Prize in Physiology or Medicine was awarded to honor their discoveries of molecular mechanisms controlling the circadian rhythm. Keywords: Circadian clocks, Circadian rhythms, Clock genes, TTFL model, 2017 Nobel Prize |
url |
http://www.sciencedirect.com/science/article/pii/S2319417018300179 |
work_keys_str_mv |
AT rongchihuang thediscoveriesofmolecularmechanismsforthecircadianrhythmthe2017nobelprizeinphysiologyormedicine AT rongchihuang discoveriesofmolecularmechanismsforthecircadianrhythmthe2017nobelprizeinphysiologyormedicine |
_version_ |
1724304483936108544 |