Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells.

Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells.

Tetraarsenic hexoxide (As4O6) has been used in Korean folk medicines for the treatment of cancer, however its anti-cancer mechanisms remain obscured. Here, this study investigated the anti-cancer effect of As4O6 on SW620 human colon cancer cells. As4O6 has showed a dose-dependent inhibition of SW620...

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Bibliographic Details
Main Authors: Arulkumar Nagappan, Won Sup Lee, Jeong Won Yun, Jing Nan Lu, Seong-Hwan Chang, Jae-Hoon Jeong, Gon Sup Kim, Jin-Myung Jung, Soon Chan Hong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5371332?pdf=render

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http://europepmc.org/articles/PMC5371332?pdf=render

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