Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities
Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us...
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doaj-ff9f01e982a94c2ca08288043a52487a2020-11-25T00:14:46ZengMDPI AGMolecules1420-30492016-04-0121556410.3390/molecules21050564molecules21050564Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic ActivitiesAnika Kuczmannová0Andrea Balažová1Eva Račanská2Miroslava Kameníková3Silvia Fialová4Jaroslav Majerník5Milan Nagy6Peter Gál7Pavel Mučaji8Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, SlovakiaDepartment of Cell and Molecular Biology of Drugs, Faculty of Pharmacy, Comenius University, Kalinčiakova 8, Bratislava 83232, SlovakiaDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, SlovakiaDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, SlovakiaDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, SlovakiaDepartment of Medical Informatics, Faculty of Medicine, Pavol Jozef Šafárik University, Trieda SNP 1, Košice 04011, SlovakiaDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, SlovakiaDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, SlovakiaDepartment of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojárov 10, Bratislava 83232, SlovakiaDiabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week period, changes in blood glucose and body weight were monitored. Then, rats were sacrificed and subjected to the assessment of changes in the reactivity of aortas and measurement of butyrylcholinesterase activity. To complete the panel of experiments, α-glucosidase activity was assessed in vitro. Our results demonstrate that both tested extracts exert similar anti-diabetic activities. However, better anti-oxidant activity of the A. eupatoria extract indicates its higher clinical potential in the prevention and/or adjuvant therapy of developing cardiovascular complications related to DM and diseases associated with oxidative stress.http://www.mdpi.com/1420-3049/21/5/564diabetes mellitusphytotherapyagrimonyartichokestreptozotocin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anika Kuczmannová Andrea Balažová Eva Račanská Miroslava Kameníková Silvia Fialová Jaroslav Majerník Milan Nagy Peter Gál Pavel Mučaji |
spellingShingle |
Anika Kuczmannová Andrea Balažová Eva Račanská Miroslava Kameníková Silvia Fialová Jaroslav Majerník Milan Nagy Peter Gál Pavel Mučaji Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities Molecules diabetes mellitus phytotherapy agrimony artichoke streptozotocin |
author_facet |
Anika Kuczmannová Andrea Balažová Eva Račanská Miroslava Kameníková Silvia Fialová Jaroslav Majerník Milan Nagy Peter Gál Pavel Mučaji |
author_sort |
Anika Kuczmannová |
title |
Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities |
title_short |
Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities |
title_full |
Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities |
title_fullStr |
Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities |
title_full_unstemmed |
Agrimonia eupatoria L. and Cynara cardunculus L. Water Infusions: Comparison of Anti-Diabetic Activities |
title_sort |
agrimonia eupatoria l. and cynara cardunculus l. water infusions: comparison of anti-diabetic activities |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2016-04-01 |
description |
Diabetes mellitus (DM) is frequently diagnosed at a time when patients already suffer from several cardiovascular complications. Our previously published data (Molecules 201520 (11): 20538-50) on the anti-oxidative properties of Agrimonia eupatoria L. (AE) and Cynara cardunculus L. (CC) prompted us to extend the available evidence on their possible protective activities on selected DM-related parameters in a streptozotocin-induced DM rat model and in a series of in vitro experiments. Male rats were divided into four groups: control group, untreated diabetic group, AE and CC treated diabetic groups. During a five-week period, changes in blood glucose and body weight were monitored. Then, rats were sacrificed and subjected to the assessment of changes in the reactivity of aortas and measurement of butyrylcholinesterase activity. To complete the panel of experiments, α-glucosidase activity was assessed in vitro. Our results demonstrate that both tested extracts exert similar anti-diabetic activities. However, better anti-oxidant activity of the A. eupatoria extract indicates its higher clinical potential in the prevention and/or adjuvant therapy of developing cardiovascular complications related to DM and diseases associated with oxidative stress. |
topic |
diabetes mellitus phytotherapy agrimony artichoke streptozotocin |
url |
http://www.mdpi.com/1420-3049/21/5/564 |
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