Iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease
Abstract Background The use of statins for primary prevention of cardiovascular diseases is associated with different benefit and harm outcomes. The aime of this study is how important these outcomes are for people and what people's preferences are. Methods We conducted a preference-eliciting s...
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doaj-ff9f899737bf44f8875163fe402726222020-11-25T04:07:37ZengBMCBMC Medical Informatics and Decision Making1472-69472020-11-0120111110.1186/s12911-020-01304-wIranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular diseaseHassan Saadati0Hamid Reza Baradaran1Goodarz Danaei2Afshin Ostovar3Farzad Hadaegh4Leila Janani5Ewout W. Steyerberg6Davood Khalili7Department of Epidemiology, School of Public Health, Iran University of Medical SciencesDepartment of Epidemiology, School of Public Health, Iran University of Medical SciencesDepartment of Global Health and Population and Department of Epidemiology, Harvard TH Chan School of Public HealthOsteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical SciencesPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesDepartment of Biostatistics, School of Public Health, Iran University of Medical SciencesDepartment of Biomedical Data Sciences, Leiden University Medical CenterPrevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical SciencesAbstract Background The use of statins for primary prevention of cardiovascular diseases is associated with different benefit and harm outcomes. The aime of this study is how important these outcomes are for people and what people's preferences are. Methods We conducted a preference-eliciting survey incorporating a best–worst scaling (BWS) instrument in Iran from June to November 2019. The relative importance of 13 statins-related outcomes was assessed on a sample of 1085 participants, including 913 general population (486 women) and 172 healthcare providers from the population covered by urban and rural primary health care centers. The participants made trade-off decisions and selected the most and least worrisome outcomes concurrently from 13 choice sets; each contains four outcomes generated using the balanced incomplete block design. Results According to the mean (SD) BWS scores, which can be (+ 4) in maximum and (− 4) in minimum, in the general population, the most worrisome outcomes were severe stroke (3.37 (0.8)), severe myocardial infarction (2.71(0.7)), and cancer (2.69 (1.33)). While myopathy (− 3. 03 (1.03)), nausea/headache (− 2.69 (0.94)), and treatment discontinuation due to side effects (− 2.24 (1.14)) were the least worrisome outcomes. Preferences were similar between rural and urban areas and among health care providers and the general population with overlapping uncertainty intervals. Conclusion The rank of health outcomes may be similar in various socio-cultural contexts. The preferences for benefits and harms of statin therapy are essential to assess benefit-harm balance when recommending statins for primary prevention of cardiovascular diseases.http://link.springer.com/article/10.1186/s12911-020-01304-wPreferencesStatinsBenefit harm outcomesPrimary preventionCardiovascular disease |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hassan Saadati Hamid Reza Baradaran Goodarz Danaei Afshin Ostovar Farzad Hadaegh Leila Janani Ewout W. Steyerberg Davood Khalili |
spellingShingle |
Hassan Saadati Hamid Reza Baradaran Goodarz Danaei Afshin Ostovar Farzad Hadaegh Leila Janani Ewout W. Steyerberg Davood Khalili Iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease BMC Medical Informatics and Decision Making Preferences Statins Benefit harm outcomes Primary prevention Cardiovascular disease |
author_facet |
Hassan Saadati Hamid Reza Baradaran Goodarz Danaei Afshin Ostovar Farzad Hadaegh Leila Janani Ewout W. Steyerberg Davood Khalili |
author_sort |
Hassan Saadati |
title |
Iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease |
title_short |
Iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease |
title_full |
Iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease |
title_fullStr |
Iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease |
title_full_unstemmed |
Iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease |
title_sort |
iranian general populations' and health care providers' preferences for benefits and harms of statin therapy for primary prevention of cardiovascular disease |
publisher |
BMC |
series |
BMC Medical Informatics and Decision Making |
issn |
1472-6947 |
publishDate |
2020-11-01 |
description |
Abstract Background The use of statins for primary prevention of cardiovascular diseases is associated with different benefit and harm outcomes. The aime of this study is how important these outcomes are for people and what people's preferences are. Methods We conducted a preference-eliciting survey incorporating a best–worst scaling (BWS) instrument in Iran from June to November 2019. The relative importance of 13 statins-related outcomes was assessed on a sample of 1085 participants, including 913 general population (486 women) and 172 healthcare providers from the population covered by urban and rural primary health care centers. The participants made trade-off decisions and selected the most and least worrisome outcomes concurrently from 13 choice sets; each contains four outcomes generated using the balanced incomplete block design. Results According to the mean (SD) BWS scores, which can be (+ 4) in maximum and (− 4) in minimum, in the general population, the most worrisome outcomes were severe stroke (3.37 (0.8)), severe myocardial infarction (2.71(0.7)), and cancer (2.69 (1.33)). While myopathy (− 3. 03 (1.03)), nausea/headache (− 2.69 (0.94)), and treatment discontinuation due to side effects (− 2.24 (1.14)) were the least worrisome outcomes. Preferences were similar between rural and urban areas and among health care providers and the general population with overlapping uncertainty intervals. Conclusion The rank of health outcomes may be similar in various socio-cultural contexts. The preferences for benefits and harms of statin therapy are essential to assess benefit-harm balance when recommending statins for primary prevention of cardiovascular diseases. |
topic |
Preferences Statins Benefit harm outcomes Primary prevention Cardiovascular disease |
url |
http://link.springer.com/article/10.1186/s12911-020-01304-w |
work_keys_str_mv |
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