Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-Review
Iron toxicity within cardiomyocytes is considered as the main pathogenesis of cardiac dysfunction in transfusion dependent thalassemia (TDT). Various methods such as measuring serum ferritin, evaluating cardiac functional and structural parameters by either cardiac magnetic resonance imaging (CMRI)...
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Zabol University of Medical sciences
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doaj-ffacaa69e1604b619da5a79eadd980a32020-11-24T21:23:56ZengZabol University of Medical sciencesInternational Journal of Basic Science in Medicine2476-664X2017-03-012151010.15171/ijbsm.2017.02IJBSM-2084-20170225232212Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-ReviewAli Bazi0Mohammad Reza Keramati1Iraj Shahramian2Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University of Medical Sciences, Zabol, IranFaculty of Medicine, Cancer Molecular Pathology Research Center, Emam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pediatrics, Zabol University of Medical Sciences, Zabol, IranIron toxicity within cardiomyocytes is considered as the main pathogenesis of cardiac dysfunction in transfusion dependent thalassemia (TDT). Various methods such as measuring serum ferritin, evaluating cardiac functional and structural parameters by either cardiac magnetic resonance imaging (CMRI) or echocardiography, and monitoring the heart rate variability (HRV) have been proposed to monitor cardiac iron content in patients. High inconsistency is present regarding predictability of various parameters derived by each of these methods in order to predict the cardiac iron overload. The aim of present review was to grasp the most appropriate parameters predicting cardiac hemosiderosis in TDT. Predicating values for cardiac iron deposition of the most in-use indicators such as ferritin, cardiac T2* relaxation time, left ventricular ejection fraction (LVEF), and HRV were discussed. In addition, a description on the most effective preventive measures for cardiac hemosiderosis was provided.http://ijbsm.zbmu.ac.ir/PDF/IJBSM-2-5.pdfCardiomyopathyHeartHemosiderosisThalassemiaMagnetic resonance imaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Bazi Mohammad Reza Keramati Iraj Shahramian |
spellingShingle |
Ali Bazi Mohammad Reza Keramati Iraj Shahramian Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-Review International Journal of Basic Science in Medicine Cardiomyopathy Heart Hemosiderosis Thalassemia Magnetic resonance imaging |
author_facet |
Ali Bazi Mohammad Reza Keramati Iraj Shahramian |
author_sort |
Ali Bazi |
title |
Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-Review |
title_short |
Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-Review |
title_full |
Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-Review |
title_fullStr |
Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-Review |
title_full_unstemmed |
Cardiac Hemosiderosis in Transfusion DependentThalassemia: A Mini-Review |
title_sort |
cardiac hemosiderosis in transfusion dependentthalassemia: a mini-review |
publisher |
Zabol University of Medical sciences |
series |
International Journal of Basic Science in Medicine |
issn |
2476-664X |
publishDate |
2017-03-01 |
description |
Iron toxicity within cardiomyocytes is considered as the main pathogenesis of cardiac dysfunction in transfusion dependent thalassemia (TDT). Various methods such as measuring serum ferritin, evaluating cardiac functional and structural parameters by either cardiac magnetic resonance imaging (CMRI) or echocardiography, and monitoring the heart rate variability (HRV) have been proposed to monitor cardiac iron content in patients. High inconsistency is present regarding predictability of various parameters derived by each of these methods in order to predict the cardiac iron overload. The aim of present review was to grasp the most appropriate parameters predicting cardiac hemosiderosis in TDT. Predicating values for cardiac iron deposition of the most in-use indicators such as ferritin, cardiac T2* relaxation time, left ventricular ejection fraction (LVEF), and HRV were discussed. In addition, a description on the most effective preventive measures for cardiac hemosiderosis was provided. |
topic |
Cardiomyopathy Heart Hemosiderosis Thalassemia Magnetic resonance imaging |
url |
http://ijbsm.zbmu.ac.ir/PDF/IJBSM-2-5.pdf |
work_keys_str_mv |
AT alibazi cardiachemosiderosisintransfusiondependentthalassemiaaminireview AT mohammadrezakeramati cardiachemosiderosisintransfusiondependentthalassemiaaminireview AT irajshahramian cardiachemosiderosisintransfusiondependentthalassemiaaminireview |
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1725990288833380352 |