Genomic instability and cancer: lessons from Drosophila
Cancer is a genetic disease that involves the gradual accumulation of mutations. Human tumours are genetically unstable. However, the current knowledge about the origins and implications of genomic instability in this disease is limited. Understanding the biology of cancer requires the use of animal...
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2020-06-01
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Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200060 |
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doaj-ffacf5a8cd8b4ce58cb6d1c530ec308d2020-11-25T02:06:36ZengThe Royal SocietyOpen Biology2046-24412020-06-0110610.1098/rsob.200060200060Genomic instability and cancer: lessons from DrosophilaStephan U. GerlachHéctor HerranzCancer is a genetic disease that involves the gradual accumulation of mutations. Human tumours are genetically unstable. However, the current knowledge about the origins and implications of genomic instability in this disease is limited. Understanding the biology of cancer requires the use of animal models. Here, we review relevant studies addressing the implications of genomic instability in cancer by using the fruit fly, Drosophila melanogaster, as a model system. We discuss how this invertebrate has helped us to expand the current knowledge about the mechanisms involved in genomic instability and how this hallmark of cancer influences disease progression.https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200060drosophilagenomic instabilitydna damagecanceraneuploidy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stephan U. Gerlach Héctor Herranz |
spellingShingle |
Stephan U. Gerlach Héctor Herranz Genomic instability and cancer: lessons from Drosophila Open Biology drosophila genomic instability dna damage cancer aneuploidy |
author_facet |
Stephan U. Gerlach Héctor Herranz |
author_sort |
Stephan U. Gerlach |
title |
Genomic instability and cancer: lessons from Drosophila |
title_short |
Genomic instability and cancer: lessons from Drosophila |
title_full |
Genomic instability and cancer: lessons from Drosophila |
title_fullStr |
Genomic instability and cancer: lessons from Drosophila |
title_full_unstemmed |
Genomic instability and cancer: lessons from Drosophila |
title_sort |
genomic instability and cancer: lessons from drosophila |
publisher |
The Royal Society |
series |
Open Biology |
issn |
2046-2441 |
publishDate |
2020-06-01 |
description |
Cancer is a genetic disease that involves the gradual accumulation of mutations. Human tumours are genetically unstable. However, the current knowledge about the origins and implications of genomic instability in this disease is limited. Understanding the biology of cancer requires the use of animal models. Here, we review relevant studies addressing the implications of genomic instability in cancer by using the fruit fly, Drosophila melanogaster, as a model system. We discuss how this invertebrate has helped us to expand the current knowledge about the mechanisms involved in genomic instability and how this hallmark of cancer influences disease progression. |
topic |
drosophila genomic instability dna damage cancer aneuploidy |
url |
https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200060 |
work_keys_str_mv |
AT stephanugerlach genomicinstabilityandcancerlessonsfromdrosophila AT hectorherranz genomicinstabilityandcancerlessonsfromdrosophila |
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1724933011749732352 |