Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells.

Small molecules have been shown to be potent and selective probes to understand cell physiology. Here, we show that imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines compose a class of compounds that target essential, conserved cellular processes. Using validated chemogenomic assays in Saccharom...

Full description

Bibliographic Details
Main Authors: Lisa Yu, Andres Lopez, Abderrahmane Anaflous, Brahim El Bali, Abdellah Hamal, Elke Ericson, Lawrence E Heisler, Angus McQuibban, Guri Giaever, Corey Nislow, Charles Boone, Grant W Brown, Mohammed Bellaoui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-11-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2583946?pdf=render

Internet

http://europepmc.org/articles/PMC2583946?pdf=render

Similar Items