Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers
Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of...
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Elsevier
2016-11-01
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Series: | Cell Reports |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124716314061 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroto Hatakeyama Sherry Y. Wu Yasmin A. Lyons Sunila Pradeep Wanqin Wang Qian Huang Karem A. Court Tao Liu Song Nie Cristian Rodriguez-Aguayo Fangrong Shen Yan Huang Takeshi Hisamatsu Takashi Mitamura Nicholas Jennings Jeajun Shim Piotr L. Dorniak Lingegowda S. Mangala Marco Petrillo Vladislav A. Petyuk Athena A. Schepmoes Anil K. Shukla Madeline Torres-Lugo Ju-Seog Lee Karin D. Rodland Anna Fagotti Gabriel Lopez-Berestein Chun Li Anil K. Sood |
spellingShingle |
Hiroto Hatakeyama Sherry Y. Wu Yasmin A. Lyons Sunila Pradeep Wanqin Wang Qian Huang Karem A. Court Tao Liu Song Nie Cristian Rodriguez-Aguayo Fangrong Shen Yan Huang Takeshi Hisamatsu Takashi Mitamura Nicholas Jennings Jeajun Shim Piotr L. Dorniak Lingegowda S. Mangala Marco Petrillo Vladislav A. Petyuk Athena A. Schepmoes Anil K. Shukla Madeline Torres-Lugo Ju-Seog Lee Karin D. Rodland Anna Fagotti Gabriel Lopez-Berestein Chun Li Anil K. Sood Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers Cell Reports hyperthermia ovarian cancer CTGF DOPC-liposome thermosensitivity copper sulfide nanoparticle |
author_facet |
Hiroto Hatakeyama Sherry Y. Wu Yasmin A. Lyons Sunila Pradeep Wanqin Wang Qian Huang Karem A. Court Tao Liu Song Nie Cristian Rodriguez-Aguayo Fangrong Shen Yan Huang Takeshi Hisamatsu Takashi Mitamura Nicholas Jennings Jeajun Shim Piotr L. Dorniak Lingegowda S. Mangala Marco Petrillo Vladislav A. Petyuk Athena A. Schepmoes Anil K. Shukla Madeline Torres-Lugo Ju-Seog Lee Karin D. Rodland Anna Fagotti Gabriel Lopez-Berestein Chun Li Anil K. Sood |
author_sort |
Hiroto Hatakeyama |
title |
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers |
title_short |
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers |
title_full |
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers |
title_fullStr |
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers |
title_full_unstemmed |
Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine Cancers |
title_sort |
role of ctgf in sensitivity to hyperthermia in ovarian and uterine cancers |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2016-11-01 |
description |
Even though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers. |
topic |
hyperthermia ovarian cancer CTGF DOPC-liposome thermosensitivity copper sulfide nanoparticle |
url |
http://www.sciencedirect.com/science/article/pii/S2211124716314061 |
work_keys_str_mv |
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doaj-ffc25263dff34e019722e07e71d9ce5f2020-11-25T01:39:03ZengElsevierCell Reports2211-12472016-11-011761621163110.1016/j.celrep.2016.10.020Role of CTGF in Sensitivity to Hyperthermia in Ovarian and Uterine CancersHiroto Hatakeyama0Sherry Y. Wu1Yasmin A. Lyons2Sunila Pradeep3Wanqin Wang4Qian Huang5Karem A. Court6Tao Liu7Song Nie8Cristian Rodriguez-Aguayo9Fangrong Shen10Yan Huang11Takeshi Hisamatsu12Takashi Mitamura13Nicholas Jennings14Jeajun Shim15Piotr L. Dorniak16Lingegowda S. Mangala17Marco Petrillo18Vladislav A. Petyuk19Athena A. Schepmoes20Anil K. Shukla21Madeline Torres-Lugo22Ju-Seog Lee23Karin D. Rodland24Anna Fagotti25Gabriel Lopez-Berestein26Chun Li27Anil K. Sood28Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Cancer Systems Imaging, MDACC, Houston, TX 77030, USADepartment of Cancer Systems Imaging, MDACC, Houston, TX 77030, USADepartment of Chemical Engineering, University of Puerto Rico-Mayaguez, Mayaguez, PR 00681, Puerto RicoBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USABiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USADepartment of Experimental Therapeutics, MDACC, Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Systems Biology, MDACC, Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USADepartment of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome 00168, ItalyBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USABiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USABiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USADepartment of Chemical Engineering, University of Puerto Rico-Mayaguez, Mayaguez, PR 00681, Puerto RicoDepartment of Systems Biology, MDACC, Houston, TX 77030, USABiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USADepartment of Medicine and Surgery, Catholic University of the Sacred Heart, Rome 00168, ItalyDepartment of Experimental Therapeutics, MDACC, Houston, TX 77030, USADepartment of Cancer Systems Imaging, MDACC, Houston, TX 77030, USADepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center (MDACC), Houston, TX 77030, USAEven though hyperthermia is a promising treatment for cancer, the relationship between specific temperatures and clinical benefits and predictors of sensitivity of cancer to hyperthermia is poorly understood. Ovarian and uterine tumors have diverse hyperthermia sensitivities. Integrative analyses of the specific gene signatures and the differences in response to hyperthermia between hyperthermia-sensitive and -resistant cancer cells identified CTGF as a key regulator of sensitivity. CTGF silencing sensitized resistant cells to hyperthermia. CTGF small interfering RNA (siRNA) treatment also sensitized resistant cancers to localized hyperthermia induced by copper sulfide nanoparticles and near-infrared laser in orthotopic ovarian cancer models. CTGF silencing aggravated energy stress induced by hyperthermia and enhanced apoptosis of hyperthermia-resistant cancers.http://www.sciencedirect.com/science/article/pii/S2211124716314061hyperthermiaovarian cancerCTGFDOPC-liposomethermosensitivitycopper sulfide nanoparticle |