Cardiac Progenitor Cells and the Interplay with Their Microenvironment

The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these nic...

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Main Authors:	Arianna Mauretti, Sergio Spaans, Noortje A. M. Bax, Cecilia Sahlgren, Carlijn V. C. Bouten
Format:	Article
Language:	English
Published:	Hindawi Limited 2017-01-01
Series:	Stem Cells International
Online Access:	http://dx.doi.org/10.1155/2017/7471582

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spelling	doaj-ffc6f737b5ea430e98a023e5158e28f72020-11-24T20:54:27ZengHindawi LimitedStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/74715827471582Cardiac Progenitor Cells and the Interplay with Their MicroenvironmentArianna Mauretti0Sergio Spaans1Noortje A. M. Bax2Cecilia Sahlgren3Carlijn V. C. Bouten4Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsDepartment of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, NetherlandsThe microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.http://dx.doi.org/10.1155/2017/7471582
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Arianna Mauretti Sergio Spaans Noortje A. M. Bax Cecilia Sahlgren Carlijn V. C. Bouten
spellingShingle	Arianna Mauretti Sergio Spaans Noortje A. M. Bax Cecilia Sahlgren Carlijn V. C. Bouten Cardiac Progenitor Cells and the Interplay with Their Microenvironment Stem Cells International
author_facet	Arianna Mauretti Sergio Spaans Noortje A. M. Bax Cecilia Sahlgren Carlijn V. C. Bouten
author_sort	Arianna Mauretti
title	Cardiac Progenitor Cells and the Interplay with Their Microenvironment
title_short	Cardiac Progenitor Cells and the Interplay with Their Microenvironment
title_full	Cardiac Progenitor Cells and the Interplay with Their Microenvironment
title_fullStr	Cardiac Progenitor Cells and the Interplay with Their Microenvironment
title_full_unstemmed	Cardiac Progenitor Cells and the Interplay with Their Microenvironment
title_sort	cardiac progenitor cells and the interplay with their microenvironment
publisher	Hindawi Limited
series	Stem Cells International
issn	1687-966X 1687-9678
publishDate	2017-01-01
description	The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells. In this review, we discuss cardiac resident progenitor cells and their regenerative potential and provide an overview of the interactions of CPCs with the key elements of their niche. We focus on the interaction between CPCs and supporting cells, extracellular matrix, mechanical stimuli, and soluble factors. Finally, we describe novel approaches to modulate the CPC niche that can represent the next step in recreating an optimal CPC microenvironment and thereby improve their regeneration capacity.
url	http://dx.doi.org/10.1155/2017/7471582
work_keys_str_mv	AT ariannamauretti cardiacprogenitorcellsandtheinterplaywiththeirmicroenvironment AT sergiospaans cardiacprogenitorcellsandtheinterplaywiththeirmicroenvironment AT noortjeambax cardiacprogenitorcellsandtheinterplaywiththeirmicroenvironment AT ceciliasahlgren cardiacprogenitorcellsandtheinterplaywiththeirmicroenvironment AT carlijnvcbouten cardiacprogenitorcellsandtheinterplaywiththeirmicroenvironment
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Cardiac Progenitor Cells and the Interplay with Their Microenvironment

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