A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs
Genetic disorders are very frequent in dogs but evaluating individualized risks of their occurrence can be uncertain. Bayesian networks are tools to characterize and analyze such events. The paper illustrates their benefits and challenges in answering two typical questions in genetic counselling: (1...
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doaj-ffc906a2df9445b6afed6c40bb676cca2020-11-25T02:45:34ZengMDPI AGAnimals2076-26152020-06-01101104110410.3390/ani10061104A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in DogsJohann. C. Detilleux0Fundamental and Applied Research in Animal Health (FARAH), Veterinary Faculty, University of Liege, Quartier Vallée 2, 6 Avenue de Cureghem, 4000 Liège, BelgiumGenetic disorders are very frequent in dogs but evaluating individualized risks of their occurrence can be uncertain. Bayesian networks are tools to characterize and analyze such events. The paper illustrates their benefits and challenges in answering two typical questions in genetic counselling: (1) What is the probability of a test-positive animal showing clinical signs of the disease? (2) What is the risk of testing positive for the mutant allele when one parent presents clinical signs? Current limited knowledge on the hereditary mode of transmission of degenerative myelopathy and on the effects of sex, diet, exercise regimen and age on the occurrence of clinical signs concurrent with the finding of the deleterious mutation was retrieved from the scientific literature. Uncertainty on this information was converted into prior Beta distributions and leaky-noisy OR models were used to construct the conditional probability tables necessary to answer the questions. Results showed the network is appropriate to answer objectively and transparently both questions under a variety of scenarios. Once users of the network have agreed with its structure and the values of the priors, computations are straightforward. The network can be updated automatically and can be represented visually so interactive discussion are easy between the veterinarian and his/her interlocutor.https://www.mdpi.com/2076-2615/10/6/1104disease controlanimalpreventiondecision supportgenetics |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Johann. C. Detilleux |
spellingShingle |
Johann. C. Detilleux A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs Animals disease control animal prevention decision support genetics |
author_facet |
Johann. C. Detilleux |
author_sort |
Johann. C. Detilleux |
title |
A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs |
title_short |
A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs |
title_full |
A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs |
title_fullStr |
A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs |
title_full_unstemmed |
A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs |
title_sort |
leaky noisy-or bayesian network applied to genetic counseling in dogs |
publisher |
MDPI AG |
series |
Animals |
issn |
2076-2615 |
publishDate |
2020-06-01 |
description |
Genetic disorders are very frequent in dogs but evaluating individualized risks of their occurrence can be uncertain. Bayesian networks are tools to characterize and analyze such events. The paper illustrates their benefits and challenges in answering two typical questions in genetic counselling: (1) What is the probability of a test-positive animal showing clinical signs of the disease? (2) What is the risk of testing positive for the mutant allele when one parent presents clinical signs? Current limited knowledge on the hereditary mode of transmission of degenerative myelopathy and on the effects of sex, diet, exercise regimen and age on the occurrence of clinical signs concurrent with the finding of the deleterious mutation was retrieved from the scientific literature. Uncertainty on this information was converted into prior Beta distributions and leaky-noisy OR models were used to construct the conditional probability tables necessary to answer the questions. Results showed the network is appropriate to answer objectively and transparently both questions under a variety of scenarios. Once users of the network have agreed with its structure and the values of the priors, computations are straightforward. The network can be updated automatically and can be represented visually so interactive discussion are easy between the veterinarian and his/her interlocutor. |
topic |
disease control animal prevention decision support genetics |
url |
https://www.mdpi.com/2076-2615/10/6/1104 |
work_keys_str_mv |
AT johanncdetilleux aleakynoisyorbayesiannetworkappliedtogeneticcounselingindogs AT johanncdetilleux leakynoisyorbayesiannetworkappliedtogeneticcounselingindogs |
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