An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development
<p>Acinar cell carcinoma of the pancreas is an uncommon malignancy, accounting for less than 1% of all pancreatic neoplasms. Because of its rarity, only a few retrospective studies are available to help guide management. We report the case of a patient with metastatic ACC who achieved prolonge...
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doaj-ffced2b1c8f64646b2d3cdbbca79d3572020-11-24T23:53:19ZengIvyspring International PublisherJournal of Cancer1837-96642011-01-0121142152An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line DevelopmentMatthew D. Armstrong, Daniel Von Hoff, Bruce Barber, Laura A. Marlow, Christina von Roemeling, Simon J. Cooper, Patrick Travis, Elizabeth Campbell, Ricardo Paz-Fumagalli, John A. Copland, Gerardo Colon-Otero<p>Acinar cell carcinoma of the pancreas is an uncommon malignancy, accounting for less than 1% of all pancreatic neoplasms. Because of its rarity, only a few retrospective studies are available to help guide management. We report the case of a patient with metastatic ACC who achieved prolonged survival as a result of personalized treatment designed in part on the basis of molecular and in-vitro data collected on analysis of the tumor and a cell line developed from the liver metastasis. To our knowledge, this represents the first human cell line of ACC. The molecular findings on this case and this patient's cell line may be of use in the management of future cases of this rare tumor and allow the identification of potential novel targets for the effective treatment of this disease.</p>http://www.jcancer.org/v02p0142.htm |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthew D. Armstrong, Daniel Von Hoff, Bruce Barber, Laura A. Marlow, Christina von Roemeling, Simon J. Cooper, Patrick Travis, Elizabeth Campbell, Ricardo Paz-Fumagalli, John A. Copland, Gerardo Colon-Otero |
spellingShingle |
Matthew D. Armstrong, Daniel Von Hoff, Bruce Barber, Laura A. Marlow, Christina von Roemeling, Simon J. Cooper, Patrick Travis, Elizabeth Campbell, Ricardo Paz-Fumagalli, John A. Copland, Gerardo Colon-Otero An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development Journal of Cancer |
author_facet |
Matthew D. Armstrong, Daniel Von Hoff, Bruce Barber, Laura A. Marlow, Christina von Roemeling, Simon J. Cooper, Patrick Travis, Elizabeth Campbell, Ricardo Paz-Fumagalli, John A. Copland, Gerardo Colon-Otero |
author_sort |
Matthew D. Armstrong, Daniel Von Hoff, Bruce Barber, Laura A. Marlow, Christina von Roemeling, Simon J. Cooper, Patrick Travis, Elizabeth Campbell, Ricardo Paz-Fumagalli, John A. Copland, Gerardo Colon-Otero |
title |
An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development |
title_short |
An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development |
title_full |
An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development |
title_fullStr |
An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development |
title_full_unstemmed |
An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development |
title_sort |
effective personalized approach to a rare tumor: prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development |
publisher |
Ivyspring International Publisher |
series |
Journal of Cancer |
issn |
1837-9664 |
publishDate |
2011-01-01 |
description |
<p>Acinar cell carcinoma of the pancreas is an uncommon malignancy, accounting for less than 1% of all pancreatic neoplasms. Because of its rarity, only a few retrospective studies are available to help guide management. We report the case of a patient with metastatic ACC who achieved prolonged survival as a result of personalized treatment designed in part on the basis of molecular and in-vitro data collected on analysis of the tumor and a cell line developed from the liver metastasis. To our knowledge, this represents the first human cell line of ACC. The molecular findings on this case and this patient's cell line may be of use in the management of future cases of this rare tumor and allow the identification of potential novel targets for the effective treatment of this disease.</p> |
url |
http://www.jcancer.org/v02p0142.htm |
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