Renewed proliferation in adult mouse cochlea and regeneration of hair cells

The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.

Bibliographic Details
Main Authors:	Yilai Shu, Wenyan Li, Mingqian Huang, Yi-Zhou Quan, Deborah Scheffer, Chunjie Tian, Yong Tao, Xuezhong Liu, Konrad Hochedlinger, Artur A. Indzhykulian, Zhengmin Wang, Huawei Li, Zheng-Yi Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-12-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-13157-7

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spelling	doaj-ffede07f9adb4b84bc66e2e78aa02c572021-05-11T12:26:35ZengNature Publishing GroupNature Communications2041-17232019-12-0110111510.1038/s41467-019-13157-7Renewed proliferation in adult mouse cochlea and regeneration of hair cellsYilai Shu0Wenyan Li1Mingqian Huang2Yi-Zhou Quan3Deborah Scheffer4Chunjie Tian5Yong Tao6Xuezhong Liu7Konrad Hochedlinger8Artur A. Indzhykulian9Zhengmin Wang10Huawei Li11Zheng-Yi Chen12Department of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolDepartment of Otolaryngology, University of Miami School of MedicineDepartment of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General HospitalDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedcial Sciences, Fudan UniversityENT Institute and Otorhinolaryngology Department of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Institutes of Biomedcial Sciences, Fudan UniversityDepartment of Otolaryngology-Head and Neck Surgery, Graduate Program in Speech and Hearing Bioscience and Techology and Program in Neuroscience, Harvard Medical SchoolThe adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.https://doi.org/10.1038/s41467-019-13157-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yilai Shu Wenyan Li Mingqian Huang Yi-Zhou Quan Deborah Scheffer Chunjie Tian Yong Tao Xuezhong Liu Konrad Hochedlinger Artur A. Indzhykulian Zhengmin Wang Huawei Li Zheng-Yi Chen
spellingShingle	Yilai Shu Wenyan Li Mingqian Huang Yi-Zhou Quan Deborah Scheffer Chunjie Tian Yong Tao Xuezhong Liu Konrad Hochedlinger Artur A. Indzhykulian Zhengmin Wang Huawei Li Zheng-Yi Chen Renewed proliferation in adult mouse cochlea and regeneration of hair cells Nature Communications
author_facet	Yilai Shu Wenyan Li Mingqian Huang Yi-Zhou Quan Deborah Scheffer Chunjie Tian Yong Tao Xuezhong Liu Konrad Hochedlinger Artur A. Indzhykulian Zhengmin Wang Huawei Li Zheng-Yi Chen
author_sort	Yilai Shu
title	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_short	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_full	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_fullStr	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_full_unstemmed	Renewed proliferation in adult mouse cochlea and regeneration of hair cells
title_sort	renewed proliferation in adult mouse cochlea and regeneration of hair cells
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-12-01
description	The adult mammalian inner ear cells cannot regenerate nor proliferate. Here, the authors show that co-activation of Myc and NOTCH pathways can stimulate proliferation of inner ear sensory epithelial cells, which can be induced to become hair cell-like cells in vitro and in vivo.
url	https://doi.org/10.1038/s41467-019-13157-7
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Renewed proliferation in adult mouse cochlea and regeneration of hair cells

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