The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and aut...

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Main Authors:	Ting Yuan, Karthika Annamalai, Shruti Naik, Blaz Lupse, Shirin Geravandi, Anasua Pal, Aleksandra Dobrowolski, Jaee Ghawali, Marina Ruhlandt, Kanaka Durga Devi Gorrepati, Zahra Azizi, Dae-Sik Lim, Kathrin Maedler, Amin Ardestani
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-25145-x

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spelling	doaj-fff43c630ec94cdfb9d466891db5de812021-08-15T11:40:42ZengNature Publishing GroupNature Communications2041-17232021-08-0112111810.1038/s41467-021-25145-xThe Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axisTing Yuan0Karthika Annamalai1Shruti Naik2Blaz Lupse3Shirin Geravandi4Anasua Pal5Aleksandra Dobrowolski6Jaee Ghawali7Marina Ruhlandt8Kanaka Durga Devi Gorrepati9Zahra Azizi10Dae-Sik Lim11Kathrin Maedler12Amin Ardestani13Centre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenDepartment of Biological Sciences, KAIST 291 Daehak-ro, Yuseong-guCentre for Biomolecular Interactions Bremen, University of BremenCentre for Biomolecular Interactions Bremen, University of BremenDiabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.https://doi.org/10.1038/s41467-021-25145-x
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ting Yuan Karthika Annamalai Shruti Naik Blaz Lupse Shirin Geravandi Anasua Pal Aleksandra Dobrowolski Jaee Ghawali Marina Ruhlandt Kanaka Durga Devi Gorrepati Zahra Azizi Dae-Sik Lim Kathrin Maedler Amin Ardestani
spellingShingle	Ting Yuan Karthika Annamalai Shruti Naik Blaz Lupse Shirin Geravandi Anasua Pal Aleksandra Dobrowolski Jaee Ghawali Marina Ruhlandt Kanaka Durga Devi Gorrepati Zahra Azizi Dae-Sik Lim Kathrin Maedler Amin Ardestani The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis Nature Communications
author_facet	Ting Yuan Karthika Annamalai Shruti Naik Blaz Lupse Shirin Geravandi Anasua Pal Aleksandra Dobrowolski Jaee Ghawali Marina Ruhlandt Kanaka Durga Devi Gorrepati Zahra Azizi Dae-Sik Lim Kathrin Maedler Amin Ardestani
author_sort	Ting Yuan
title	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_short	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_full	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_fullStr	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_full_unstemmed	The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis
title_sort	hippo kinase lats2 impairs pancreatic β-cell survival in diabetes through the mtorc1-autophagy axis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-08-01
description	Diabetes is characterized by dysfunction and loss of beta-cells, and promoting beta-cell survival is of therapeutic interest. Here the authors show that Large-tumor suppressor 2 (LATS2), a core component of the Hippo signaling pathway, induces beta-cell failure through mTORC1 hyperactivation and autophagic flux suppression.
url	https://doi.org/10.1038/s41467-021-25145-x
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The Hippo kinase LATS2 impairs pancreatic β-cell survival in diabetes through the mTORC1-autophagy axis

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