Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study
Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors (n=157) and a group with multiple myeloma (n=19). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zole...
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Series: | BioMed Research International |
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doaj-fffa58c142bc4f969272cf83bc9b08542020-11-25T01:06:43ZengHindawi LimitedBioMed Research International2314-61332314-61412015-01-01201510.1155/2015/936307936307Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort StudyJuan Wu0Wei Zheng1Yan Tan2Xiao-Yuan Hu3Quan Huang4Kai-Hua Fan5Jie Ma6Wen-Jing Xiao7Jian-Dong Ren8Jun Hou9Jian-Ru Xiao10Department of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Orthopedics, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Science and Training, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Training, Second Military Medical University, Shanghai 200433, ChinaDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, ChinaDepartment of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Pharmacy, Chengdu Military General Hospital, Chengdu 610083, ChinaDepartment of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai 200003, ChinaBetween June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors (n=157) and a group with multiple myeloma (n=19). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zoledronic acid subgroup of the solid tumors group was group A (n=81), the control subgroup of the solid tumors group was group B (n=76), the zoledronic acid subgroup of the multiple myeloma group was group C (n=10), and the control subgroup of the multiple myeloma group was group D (n=9). The average intraoperative blood loss during spinal surgery was as follows: 1311±691 mL in group A and 1752±740 mL in group B (P=0.000) and 1994±810 mL in group C and 3134±795 mL in group D (P=0.000). Patients receiving zoledronic acid before surgery had significantly less intraoperative bleeding than those who did not receive it. Preoperative use of zoledronic acid can effectively reduce intraoperative bleeding during surgery for the treatment of spinal tumors.http://dx.doi.org/10.1155/2015/936307 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Juan Wu Wei Zheng Yan Tan Xiao-Yuan Hu Quan Huang Kai-Hua Fan Jie Ma Wen-Jing Xiao Jian-Dong Ren Jun Hou Jian-Ru Xiao |
spellingShingle |
Juan Wu Wei Zheng Yan Tan Xiao-Yuan Hu Quan Huang Kai-Hua Fan Jie Ma Wen-Jing Xiao Jian-Dong Ren Jun Hou Jian-Ru Xiao Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study BioMed Research International |
author_facet |
Juan Wu Wei Zheng Yan Tan Xiao-Yuan Hu Quan Huang Kai-Hua Fan Jie Ma Wen-Jing Xiao Jian-Dong Ren Jun Hou Jian-Ru Xiao |
author_sort |
Juan Wu |
title |
Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_short |
Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_full |
Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_fullStr |
Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_full_unstemmed |
Zoledronic Acid May Reduce Intraoperative Bleeding in Spinal Tumors: A Prospective Cohort Study |
title_sort |
zoledronic acid may reduce intraoperative bleeding in spinal tumors: a prospective cohort study |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2015-01-01 |
description |
Between June 2010 and June 2011, 176 patients were divided into 2 groups: a group with spinal metastasis of solid tumors (n=157) and a group with multiple myeloma (n=19). Both groups were further divided into 2 subgroups: a group receiving zoledronic acid before surgery and a control group. The zoledronic acid subgroup of the solid tumors group was group A (n=81), the control subgroup of the solid tumors group was group B (n=76), the zoledronic acid subgroup of the multiple myeloma group was group C (n=10), and the control subgroup of the multiple myeloma group was group D (n=9). The average intraoperative blood loss during spinal surgery was as follows: 1311±691 mL in group A and 1752±740 mL in group B (P=0.000) and 1994±810 mL in group C and 3134±795 mL in group D (P=0.000). Patients receiving zoledronic acid before surgery had significantly less intraoperative bleeding than those who did not receive it. Preoperative use of zoledronic acid can effectively reduce intraoperative bleeding during surgery for the treatment of spinal tumors. |
url |
http://dx.doi.org/10.1155/2015/936307 |
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