Suppression and facilitation of human neural responses
Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different methodologies (behavioral psychophysics, computational...
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doaj-fffe7b7cb7a743849917770fbe9ee2912021-05-05T15:33:17ZengeLife Sciences Publications LtdeLife2050-084X2018-01-01710.7554/eLife.30334Suppression and facilitation of human neural responsesMichael-Paul Schallmo0https://orcid.org/0000-0001-8252-8607Alexander M Kale1https://orcid.org/0000-0001-7668-2800Rachel Millin2Anastasia V Flevaris3Zoran Brkanac4Richard AE Edden5Raphael A Bernier6Scott O Murray7Department of Psychology, University of Washington, Seattle, United StatesDepartment of Psychology, University of Washington, Seattle, United StatesDepartment of Psychology, University of Washington, Seattle, United StatesDepartment of Psychology, University of Washington, Seattle, United StatesDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United StatesDepartment of Radiology and Radiological Science, Johns Hopkins University, Baltimore, United StatesDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, United StatesDepartment of Psychology, University of Washington, Seattle, United StatesEfficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression and facilitation. We show that: (1) both suppression and facilitation can emerge from a single, computational principle – divisive normalization; there is no need to invoke separate neural mechanisms, (2) neural suppression and facilitation in the motion-selective area MT mirror perception, but strong suppression also occurs in earlier visual areas, and (3) suppression is not primarily driven by GABA-mediated inhibition. Thus, while commonly used spatial suppression paradigms may provide insight into neural response magnitudes in visual areas, they should not be used to infer neural inhibition.https://elifesciences.org/articles/30334surround suppressionmotion perceptionspatial visionnormalizationGABAMT |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael-Paul Schallmo Alexander M Kale Rachel Millin Anastasia V Flevaris Zoran Brkanac Richard AE Edden Raphael A Bernier Scott O Murray |
spellingShingle |
Michael-Paul Schallmo Alexander M Kale Rachel Millin Anastasia V Flevaris Zoran Brkanac Richard AE Edden Raphael A Bernier Scott O Murray Suppression and facilitation of human neural responses eLife surround suppression motion perception spatial vision normalization GABA MT |
author_facet |
Michael-Paul Schallmo Alexander M Kale Rachel Millin Anastasia V Flevaris Zoran Brkanac Richard AE Edden Raphael A Bernier Scott O Murray |
author_sort |
Michael-Paul Schallmo |
title |
Suppression and facilitation of human neural responses |
title_short |
Suppression and facilitation of human neural responses |
title_full |
Suppression and facilitation of human neural responses |
title_fullStr |
Suppression and facilitation of human neural responses |
title_full_unstemmed |
Suppression and facilitation of human neural responses |
title_sort |
suppression and facilitation of human neural responses |
publisher |
eLife Sciences Publications Ltd |
series |
eLife |
issn |
2050-084X |
publishDate |
2018-01-01 |
description |
Efficient neural processing depends on regulating responses through suppression and facilitation of neural activity. Utilizing a well-known visual motion paradigm that evokes behavioral suppression and facilitation, and combining five different methodologies (behavioral psychophysics, computational modeling, functional MRI, pharmacology, and magnetic resonance spectroscopy), we provide evidence that challenges commonly held assumptions about the neural processes underlying suppression and facilitation. We show that: (1) both suppression and facilitation can emerge from a single, computational principle – divisive normalization; there is no need to invoke separate neural mechanisms, (2) neural suppression and facilitation in the motion-selective area MT mirror perception, but strong suppression also occurs in earlier visual areas, and (3) suppression is not primarily driven by GABA-mediated inhibition. Thus, while commonly used spatial suppression paradigms may provide insight into neural response magnitudes in visual areas, they should not be used to infer neural inhibition. |
topic |
surround suppression motion perception spatial vision normalization GABA MT |
url |
https://elifesciences.org/articles/30334 |
work_keys_str_mv |
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