The Application of High-Throughput Technologies for the Study of Microbiome and Cancer
Human gut microbiome research, especially gut microbiome, has been developing at a considerable pace over the last decades, driven by a rapid technological advancement. The emergence of high-throughput technologies, such as genomics, transcriptomics, and others, has afforded the generation of large...
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doaj-fffef394a53a409dbb52243fdb4041e32021-07-28T10:05:39ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-07-011210.3389/fgene.2021.699793699793The Application of High-Throughput Technologies for the Study of Microbiome and CancerLu Qi Wei0Io Hong Cheong1Guang Huan Yang2Xiao Guang Li3Zisis Kozlakidis4Lei Ding5Ning Ning Liu6Hui Wang7State Key Laboratory of Oncogenes and Related Genes, Centre for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaState Key Laboratory of Oncogenes and Related Genes, Centre for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaState Key Laboratory of Oncogenes and Related Genes, Centre for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaState Key Laboratory of Oncogenes and Related Genes, Centre for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaInternational Agency for Research on Cancer, World Health Organization, Lyon, FranceState Key Laboratory of Oncogenes and Related Genes, Centre for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaState Key Laboratory of Oncogenes and Related Genes, Centre for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaState Key Laboratory of Oncogenes and Related Genes, Centre for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaHuman gut microbiome research, especially gut microbiome, has been developing at a considerable pace over the last decades, driven by a rapid technological advancement. The emergence of high-throughput technologies, such as genomics, transcriptomics, and others, has afforded the generation of large volumes of data, and in relation to specific pathologies such as different cancer types. The current review identifies high-throughput technologies as they have been implemented in the study of microbiome and cancer. Four main thematic areas have emerged: the characterization of microbial diversity and composition, microbial functional analyses, biomarker prediction, and, lastly, potential therapeutic applications. The majority of studies identified focus on the microbiome diversity characterization, which is reaching technological maturity, while the remaining three thematic areas could be described as emerging.https://www.frontiersin.org/articles/10.3389/fgene.2021.699793/fullmicrobiomehigh-throughputcancermicrobiome diversityfunctional analysiscancer therapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lu Qi Wei Io Hong Cheong Guang Huan Yang Xiao Guang Li Zisis Kozlakidis Lei Ding Ning Ning Liu Hui Wang |
spellingShingle |
Lu Qi Wei Io Hong Cheong Guang Huan Yang Xiao Guang Li Zisis Kozlakidis Lei Ding Ning Ning Liu Hui Wang The Application of High-Throughput Technologies for the Study of Microbiome and Cancer Frontiers in Genetics microbiome high-throughput cancer microbiome diversity functional analysis cancer therapy |
author_facet |
Lu Qi Wei Io Hong Cheong Guang Huan Yang Xiao Guang Li Zisis Kozlakidis Lei Ding Ning Ning Liu Hui Wang |
author_sort |
Lu Qi Wei |
title |
The Application of High-Throughput Technologies for the Study of Microbiome and Cancer |
title_short |
The Application of High-Throughput Technologies for the Study of Microbiome and Cancer |
title_full |
The Application of High-Throughput Technologies for the Study of Microbiome and Cancer |
title_fullStr |
The Application of High-Throughput Technologies for the Study of Microbiome and Cancer |
title_full_unstemmed |
The Application of High-Throughput Technologies for the Study of Microbiome and Cancer |
title_sort |
application of high-throughput technologies for the study of microbiome and cancer |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2021-07-01 |
description |
Human gut microbiome research, especially gut microbiome, has been developing at a considerable pace over the last decades, driven by a rapid technological advancement. The emergence of high-throughput technologies, such as genomics, transcriptomics, and others, has afforded the generation of large volumes of data, and in relation to specific pathologies such as different cancer types. The current review identifies high-throughput technologies as they have been implemented in the study of microbiome and cancer. Four main thematic areas have emerged: the characterization of microbial diversity and composition, microbial functional analyses, biomarker prediction, and, lastly, potential therapeutic applications. The majority of studies identified focus on the microbiome diversity characterization, which is reaching technological maturity, while the remaining three thematic areas could be described as emerging. |
topic |
microbiome high-throughput cancer microbiome diversity functional analysis cancer therapy |
url |
https://www.frontiersin.org/articles/10.3389/fgene.2021.699793/full |
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