|
|
|
|
| LEADER |
01826 am a22001693u 4500 |
| 001 |
947 |
| 042 |
|
|
|a dc
|
| 100 |
1 |
0 |
|a Rosnani Hashim,
|e author
|
| 700 |
1 |
0 |
|a Shaharuddin Mohd,
|e author
|
| 700 |
1 |
0 |
|a Ang, Woan Tze
|e author
|
| 700 |
1 |
0 |
|a Wan Hamirul Bahrin Wan Kamal,
|e author
|
| 700 |
1 |
0 |
|a Shahrin Abdul Hamid,
|e author
|
| 245 |
0 |
0 |
|a Teknetium-99 perteknetat imunoglobulin G manusia sebagai agen radiofarmaseutikal dalam pengesanan inflamasi
|
| 260 |
|
|
|b penerbit ukm,
|c 2003-07.
|
| 856 |
|
|
|z Get fulltext
|u http://journalarticle.ukm.my/947/1/jurnal3.pdf
|
| 520 |
|
|
|a This study was carried out to determine the potential of technetium-99m pertechnetate Human Immunoglobulin G (***Tc.HIgG) as a radiopharmaceutical agent in the detection of inflammation site. Reduced HLgG antibody was found to be stabled at the optimal storage temperatures of -70°C and 0°C and deteriorated at 2 - N°C. The percentage of labeling of HIgG with ***Tc obtained was more than 95%. Biodistribution of ***Tc-HIgG was studied by using Sprague Dawley rats which were injected intramuscularly with turpentine to induce localized inflammation. The biodistribution of ***Tc-HIgG was determined by using immunosintigraphy (scanning) and kill and count method. Immunosintigram obtained after 4 hours post injection showed the clearest image of ***Tc-HIgG biodistribution in the inflamed muscle. The cut and count method also indicated that uptake of ***Tc-HIgG by the inflamed muscle was highest after 4 hours post injection. The pattern of ***Tc localization was different from ***Tc-HIgG. Imaging of inflamed cells using radiopharmaceutical ***Tc-HIgG, Possesses the potential to be used in the diagnosis of infection'inflammation such as in cancer or immunocompromised patients and in assessing patient's response to the therapy of inflammatory diseases.
|
| 546 |
|
|
|a en
|
