|
|
|
|
| LEADER |
01174 am a22001453u 4500 |
| 001 |
948 |
| 042 |
|
|
|a dc
|
| 100 |
1 |
0 |
|a Rosnani Hashim,
|e author
|
| 700 |
1 |
0 |
|a Tariq Abdul Razak,
|e author
|
| 700 |
1 |
0 |
|a Suhaimi Hashim,
|e author
|
| 245 |
0 |
0 |
|a Kesan in vitro rilmenidine ke atas rembesan insulin
|
| 260 |
|
|
|b penerbit ukm,
|c 2003-07.
|
| 856 |
|
|
|z Get fulltext
|u http://journalarticle.ukm.my/948/1/jurnal4.pdf
|
| 520 |
|
|
|a This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations.
|
| 546 |
|
|
|a en
|
