Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives

A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions.The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv (MTB-H37Rv) and INH-resistant M....

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Main Authors: Yeong, Keng Yoon (Author), Ali, Mohamed Ashraf (Author), Tan, Soo Choon (Author), Ismail, Rusli (Author), Ang, Chee Wei (Author), Kumar, Raju Suresh (Author), Osman, Hasnah (Author), Beevi, Farzana (Author)
Format: Article
Language:English
Published: Hindawi Publishing Corporation, 2013.
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Online Access:Get fulltext
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100 1 0 |a Yeong, Keng Yoon  |e author 
700 1 0 |a Ali, Mohamed Ashraf  |e author 
700 1 0 |a Tan, Soo Choon  |e author 
700 1 0 |a Ismail, Rusli   |e author 
700 1 0 |a Ang, Chee Wei  |e author 
700 1 0 |a Kumar, Raju Suresh  |e author 
700 1 0 |a Osman, Hasnah  |e author 
700 1 0 |a Beevi, Farzana  |e author 
245 0 0 |a Antituberculosis: Synthesis and Antimycobacterial Activity of Novel Benzimidazole Derivatives 
260 |b Hindawi Publishing Corporation,   |c 2013. 
856 |z Get fulltext  |u http://eprints.usm.my/38344/1/Antituberculosis_Synthesis_and_Antimycobacterial_Activity_of_Novel_Benzimidazole_Derivatives.pdf 
520 |a A total of seven novel benzimidazoles were synthesized by a 4-step reaction starting from 4-fluoro-3-nitrobenzoic acid under relatively mild reaction conditions.The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H37Rv (MTB-H37Rv) and INH-resistant M. tuberculosis (INHR-MTB) strains using agar dilution method. Three of them displayed good activity with MIC of less than 0.2 
546 |a en 
650 0 4 |a QD1-999 Chemistry 
650 0 4 |a R735-854 Medical education. Medical schools. Research