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01408 am a22001693u 4500 |
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18872 |
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|a dc
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|a Jully, Tan
|e author
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|a Foo Chwan Yee, Dominic
|e author
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|a Kumaresan, sivakumar
|e author
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|a Abdul Aziz, Ramlan
|e author
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|a Computer-aided process design tools for debottlenecking a batch pharmaceutical production
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|c 2008.
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|z Get fulltext
|u http://eprints.utm.my/id/eprint/18872/1/Tan%20Jully2007_COMPUTER%20AIDED%20PROCEss%20DEsIGN%20TOOLs.pdf
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|a The main objective of this work is to model and to debottleneck a batch pharmaceutical production with computer-aided process design (CAPD) and simulation tools. An eye drop production case study is firstly modelled based on a pharmaceutical production plant. Throughput analysis is next utilised to identify process bottlenecks that limit the increase of production and to evaluate different debottlenecking schemes. Scheme 1 considers an effort to maximise process throughput for a single batch operation, while Schemes 2 and 3 explore the possibility of minimising combined utilisation value of the process bottleneck. With the increase of batch throughput, installation of a new labelling process and the addition of an intermediate tank, Scheme 3 is identified as the debottlenecking scheme that achieves the increased production demand of 25%.
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