Trace level quantification of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl genotoxic impurity in trazodone using LC-MS/MS
A selective and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for the quantitative determination of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl (CCP HCl) a process related impurity in trazodone. The method provided excellent sensitivity at a typical...
Main Authors: | Venugopal, Nandigam (Author), Bhaskar Reddy, Ambavaram Vijaya (Author), Madhavi, Gajulapalle (Author), Jaafar, Jafariah (Author), Madhavi, Vemula (Author), Gangadhara Reddy, Kalluru (Author) |
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Format: | Article |
Language: | English |
Published: |
Elsevier B.V.,
2019-11.
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Subjects: | |
Online Access: | Get fulltext |
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