Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres - A review

• Main Authors: Ford Versypt, Ashlee N. (Contributor), Pack, Daniel W. (Author), Braatz, Richard D. (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
• Format: Article
• Language: English
• Published: Elsevier, 2016-02-11T01:27:56Z.
• Subjects: Article
• Online Access: Get fulltext

PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles.
National Institutes of Health (U.S.) (NIBIB 5RO1EB005181)
National Science Foundation (U.S.) (Grant 0426328)
United States. Dept. of Energy. National Nuclear Security Administration (Contract DE-FG02-97ER25308)