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|a Tschabrunn, Cory M.
|e author
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|a Massachusetts Institute of Technology. Institute for Soldier Nanotechnologies
|e contributor
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|a Massachusetts Institute of Technology. Center for Bits and Atoms
|e contributor
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|a Massachusetts Institute of Technology. Department of Architecture
|e contributor
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
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|a Massachusetts Institute of Technology. Department of Chemistry
|e contributor
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|a Massachusetts Institute of Technology. Department of Physics
|e contributor
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|a Massachusetts Institute of Technology. Media Laboratory
|e contributor
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|a Koch Institute for Integrative Cancer Research at MIT
|e contributor
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|a Program in Media Arts and Sciences
|q (Massachusetts Institute of Technology)
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|a Hsu, Bryan Boen
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|a Conway, William E.
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|a Zhang, Shuguang
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|a Hammond, Paula T.
|e contributor
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|a Mehta, Manav
|e author
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|a Perez-Cuevas, Monica B.
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|a Zhang, Shuguang
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|a Hsu, Bryan Boen
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|a Conway, William E.
|e author
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|a Hammond, Paula T
|e author
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|a Clotting Mimicry from Robust Hemostatic Bandages Based on Self-Assembling Peptides
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|b American Chemical Society (ACS),
|c 2016-02-17T15:33:09Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/101197
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|a Uncontrolled bleeding from traumatic wounds is a major factor in deaths resulting from military conflict, accidents, disasters and crime. Self-assembling peptide nanofibers have shown superior hemostatic activity, and herein, we elucidate their mechanism by visualizing the formation of nanofiber-based clots that aggregate blood components with a similar morphology to fibrin-based clots. Furthermore, to enhance its direct application to a wound, we developed layer-by-layer assembled thin film coatings onto common materials used for wound dressings-gauze and gelatin sponges. We find these nanofibers elute upon hydration under physiological conditions and generate nanofiber-based clots with blood. After exposure to a range of harsh temperature conditions (−80 to 60 °C) for a week and even 5 months at 60 °C, these hemostatic bandages remain capable of releasing active nanofibers. In addition, the application of these nanofiber-based films from gauze bandages was found to accelerate hemostasis in porcine skin wounds as compared to plain gauze. The thermal robustness, in combination with the self-assembling peptide's potent hemostatic activity, biocompatibility, biodegradability, and low cost of production, makes this a promising approach for a cheap yet effective hemostatic bandage.
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|a United States. Army Research Office (Contract W911NF-13-D-0001)
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|a United States. Air Force (Contract W911NF-07-D-0004)
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|a en_US
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|a Article
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|t ACS Nano
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