RGS9-2-controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states

RGS9-2-controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states

The striatal protein Regulator of G-protein signaling 9-2 (RGS9-2) plays a key modulatory role in opioid, monoamine, and other G-protein-coupled receptor responses. Here, we use the murine spared-nerve injury model of neuropathic pain to investigate the mechanism by which RGS9-2 in the nucleus accum...

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Main Authors: Mitsi, Vasiliki (Author), Terzi, Dimitra (Author), Purushothaman, Immanuel (Author), Manouras, Lefteris (Author), Gaspari, Sevasti (Author), Neve, Rachael L. (Contributor), Stratinaki, Maria (Author), Feng, Jian (Author), Shen, Li (Author), Zachariou, Venetia (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2016-03-02T17:37:26Z.
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