Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers

• Main Authors: Tian, Fei (Author), Min, Jouha (Contributor), Kanka, Jiri (Author), Li, Xiangzhi (Author), Du, Henry (Author), Hammond, Paula T (Author)
• Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hammond, Paula T. (Contributor)
• Format: Article
• Language: English
• Published: Optical Society of America, 2016-05-04T17:49:11Z.
• Subjects: Article
• Online Access: Get fulltext

A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions.
National Science Foundation (U.S.) (Grant DMR-1206669)
Czech Republic. Ministry of Education, Youth, and Sports (Grant LH 11038)