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|a Tian, Fei
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|a Massachusetts Institute of Technology. Department of Chemical Engineering
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|a Koch Institute for Integrative Cancer Research at MIT
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|a Hammond, Paula T.
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|a Min, Jouha
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|a Hammond, Paula T.
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|a Min, Jouha
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|a Kanka, Jiri
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|a Li, Xiangzhi
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|a Du, Henry
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|a Hammond, Paula T
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|a Lab-on-fiber optofluidic platform for in situ monitoring of drug release from therapeutic eluting polyelectrolyte multilayers
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|b Optical Society of America,
|c 2016-05-04T17:49:11Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/102405
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|a A lab-on-fiber (LOF) optofluidic platform that provides physiologically relevant microenvironment was developed by integrating a long period grating (LPG) coupled with high order cladding mode to achieve high index sensitivity and a liquid-tight capillary tube assembly as a microfluidic chamber for LPG to mimic physiologically relevant microenvironment. We demonstrate the utility of LOF for in situ monitoring the construction of the [chitosan (CHI)/poly (acrylic acid) (PAA)/gentamicin sulfate (GS)/PAA]n multilayers at monolayer resolution as well as evaluating the rate of GS release at a flow rate of 0.127 mL/min at 37 °C in real time. We reveal that GS is released at a faster rate under the dynamic flow condition than in a static medium. Our findings underscore the importance of conducting drug release studies in physiologically relevant conditions.
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|a National Science Foundation (U.S.) (Grant DMR-1206669)
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|a Czech Republic. Ministry of Education, Youth, and Sports (Grant LH 11038)
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|a en_US
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|a Article
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|t Optics Express
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