Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex

• Main Authors: Felix-Ortiz, Ada Celis (Contributor), Burgos-Robles, Anthony Noel (Contributor), Bhagat, Neha D. (Contributor), Leppla, Christopher Albert (Contributor), Tye, Kay (Contributor)
• Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
• Format: Article
• Language: English
• Published: Elsevier, 2016-05-25T00:15:44Z.
• Subjects: Article
• Online Access: Get fulltext

The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either activate or inhibit BLA inputs to the mPFC during behavioral assays that assess anxiety-like behavior and social interaction. Channelrhodopsin-2 (ChR2)-mediated activation of BLA inputs to the mPFC produced anxiogenic effects in the elevated plus maze and open field test, whereas halorhodopsin (NpHR)-mediated inhibition produced anxiolytic effects. Furthermore, activation of the BLA-mPFC pathway reduced social interaction in the resident-intruder test, whereas inhibition facilitated social interaction. These results establish a causal relationship between activity in the BLA-mPFC pathway and the bidirectional modulation of anxiety-related and social behaviors.
National Institutes of Health (U.S.) (National Research Service Award Institutional Research Training Grant 5T32GM007484-38)
Brain & Behavior Research Foundation (Young Investigator Award)
National Institute of Mental Health (U.S.) (Research Supplement to Promote Diversity in Health-Related Sciences)
Integrative Neuronal Systems Fellowship
James R. Killian Fellowship
JPB Foundation
Whitehall Foundation
Klingenstein Foundation
Alfred P. Sloan Foundation
New York Stem Cell Foundation
National Institutes of Health (U.S.) (R01-MH102441-01)