Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex

The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either...

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Bibliographic Details
Main Authors: Felix-Ortiz, Ada Celis (Contributor), Burgos-Robles, Anthony Noel (Contributor), Bhagat, Neha D. (Contributor), Leppla, Christopher Albert (Contributor), Tye, Kay (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-05-25T00:15:44Z.
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Online Access:Get fulltext
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042 |a dc 
100 1 0 |a Felix-Ortiz, Ada Celis  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences  |e contributor 
100 1 0 |a Picower Institute for Learning and Memory  |e contributor 
100 1 0 |a Felix-Ortiz, Ada Celis  |e contributor 
100 1 0 |a Burgos-Robles, Anthony Noel  |e contributor 
100 1 0 |a Bhagat, Neha D.  |e contributor 
100 1 0 |a Leppla, Christopher Albert  |e contributor 
100 1 0 |a Tye, Kay  |e contributor 
700 1 0 |a Burgos-Robles, Anthony Noel  |e author 
700 1 0 |a Bhagat, Neha D.  |e author 
700 1 0 |a Leppla, Christopher Albert  |e author 
700 1 0 |a Tye, Kay  |e author 
245 0 0 |a Bidirectional modulation of anxiety-related and social behaviors by amygdala projections to the medial prefrontal cortex 
260 |b Elsevier,   |c 2016-05-25T00:15:44Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/102671 
520 |a The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) modulate anxiety and social behaviors. It remains to be elucidated, however, whether direct projections from the BLA to the mPFC play a functional role in these behaviors. We used optogenetic approaches in behaving mice to either activate or inhibit BLA inputs to the mPFC during behavioral assays that assess anxiety-like behavior and social interaction. Channelrhodopsin-2 (ChR2)-mediated activation of BLA inputs to the mPFC produced anxiogenic effects in the elevated plus maze and open field test, whereas halorhodopsin (NpHR)-mediated inhibition produced anxiolytic effects. Furthermore, activation of the BLA-mPFC pathway reduced social interaction in the resident-intruder test, whereas inhibition facilitated social interaction. These results establish a causal relationship between activity in the BLA-mPFC pathway and the bidirectional modulation of anxiety-related and social behaviors. 
520 |a National Institutes of Health (U.S.) (National Research Service Award Institutional Research Training Grant 5T32GM007484-38) 
520 |a Brain & Behavior Research Foundation (Young Investigator Award) 
520 |a National Institute of Mental Health (U.S.) (Research Supplement to Promote Diversity in Health-Related Sciences) 
520 |a Integrative Neuronal Systems Fellowship 
520 |a James R. Killian Fellowship 
520 |a JPB Foundation 
520 |a Whitehall Foundation 
520 |a Klingenstein Foundation 
520 |a Alfred P. Sloan Foundation 
520 |a New York Stem Cell Foundation 
520 |a National Institutes of Health (U.S.) (R01-MH102441-01) 
546 |a en_US 
655 7 |a Article 
773 |t Neuroscience