Versatile Enantioselective Synthesis of Functionalized Lactones via Copper-Catalyzed Radical Oxyfunctionalization of Alkenes
A versatile method for the rapid synthesis of diverse enantiomerically enriched lactones has been developed based on Cu-catalyzed enantioselective radical oxyfunctionalization of alkenes. The scope of this strategy encompasses a series of enantioselective difunctionalization reactions: oxyazidation,...
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| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS),
2016-08-09T16:23:21Z.
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| Subjects: | |
| Online Access: | Get fulltext |
| Summary: | A versatile method for the rapid synthesis of diverse enantiomerically enriched lactones has been developed based on Cu-catalyzed enantioselective radical oxyfunctionalization of alkenes. The scope of this strategy encompasses a series of enantioselective difunctionalization reactions: oxyazidation, oxysulfonylation, oxyarylation, diacyloxylation, and oxyalkylation. These reactions provide straightforward access to a wide range of useful chiral lactone building blocks containing tetrasubstituted stereogenic centers, which are hard to access traditionally. Massachusetts Institute of Technology (Wellington and Irene Loh Fund Graduate Fellowship) National Institutes of Health (U.S.) (Grant GM58160) |
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