Pyruvate as a Pivot Point for Oncogene-Induced Senescence
Regulation of pyruvate fate is an important determinant of anabolic versus catabolic metabolism. A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might...
Main Authors: | Olenchock, Benjamin (Contributor), Vander Heiden, Matthew G. (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2016-08-11T16:08:04Z.
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Subjects: | |
Online Access: | Get fulltext |
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