Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells

Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells

Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high-affinity synthetic pThr-containing peptides provide starting points for developing PBD-directed inhibitors, to...

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Bibliographic Details
Main Authors: Qian, Wen-Jian (Author), Park, Jung-Eun (Author), Lai, Christopher C. (Author), Kelley, James A. (Author), Park, Suk-Youl (Author), Lee, Ki Won (Author), Lee, Kyung S. (Author), Burke, Terrence R. (Author), Lim, Daniel Cham-Chin (Contributor), Yaffe, Michael B (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2016-12-19T15:36:20Z.
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