Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments

Hi-C experiments explore the 3D structure of the genome, generating terabases of data to create high-resolution contact maps. Here, we introduce Juicer, an open-source tool for analyzing terabase-scale Hi-C datasets. Juicer allows users without a computational background to transform raw sequence da...

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Bibliographic Details
Main Authors: Durand, Neva C (Author), Shamim, Muhammad S (Author), Machol, Ido (Author), Rao, Suhas S.P (Author), Huntley, Miriam H (Author), Aiden, Erez Lieberman (Author), Lander, Eric Steven (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-01-31T17:15:21Z.
Subjects:
Online Access:Get fulltext
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042 |a dc 
100 1 0 |a Durand, Neva C.  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Biology  |e contributor 
100 1 0 |a Lander, Eric Steven  |e contributor 
700 1 0 |a Shamim, Muhammad S.  |e author 
700 1 0 |a Machol, Ido  |e author 
700 1 0 |a Rao, Suhas S.P.  |e author 
700 1 0 |a Huntley, Miriam H.  |e author 
700 1 0 |a Aiden, Erez Lieberman  |e author 
700 1 0 |a Lander, Eric Steven  |e author 
245 0 0 |a Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments 
260 |b Elsevier,   |c 2017-01-31T17:15:21Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/106809 
520 |a Hi-C experiments explore the 3D structure of the genome, generating terabases of data to create high-resolution contact maps. Here, we introduce Juicer, an open-source tool for analyzing terabase-scale Hi-C datasets. Juicer allows users without a computational background to transform raw sequence data into normalized contact maps with one click. Juicer produces a hic file containing compressed contact matrices at many resolutions, facilitating visualization and analysis at multiple scales. Structural features, such as loops and domains, are automatically annotated. Juicer is available as open source software at http://aidenlab.org/juicer/. 
520 |a National Institutes of Health (U.S.) (New Innovator Award 1DP2OD008540) 
520 |a National Science Foundation (U.S.) Physics Frontier Center (Grant PHY-1427654) 
520 |a National Human Genome Research Institute (U.S.) (Grant HG006193) 
520 |a Robert A. Welch Foundation (Grant Q-1866) 
520 |a Cancer Prevention and Research Institute of Texas (Scholar Award R1304) 
520 |a NVIDIA Corporation (Research Center Award) 
520 |a IBM (University Challenge Award) 
520 |a Google (Research Award) 
520 |a Baylor College of Medicine (McNair Medical Institute Scholar Award) 
520 |a National Human Genome Research Institute (U.S.) (Grant HG003067) 
520 |a National Institutes of Health (U.S.) (4D Nucleome Grant U01HL130010) 
546 |a en_US 
655 7 |a Article 
773 |t Cell Systems