Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX
ATP-dependent protein remodeling and unfolding enzymes are key participants in protein metabolism in all cells. How these often-destructive enzymes specifically recognize target protein complexes is poorly understood. Here, we use the well-studied AAA + unfoldase-substrate pair, Escherichia coli Clp...
Main Authors: | Montaño, Sherwin P. (Author), Rice, Phoebe A. (Author), Sauer, Robert T. (Contributor), Baker, Tania (Contributor), Ling, Lorraine, Ph. D. Massachusetts Institute of Technology (Author) |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Ling, Lorraine (Contributor) |
Format: | Article |
Language: | English |
Published: |
Elsevier,
2017-03-31T13:57:24Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Design framework of the MuA remodeling signal that confers preferential complex disassembly by the AAA+ unfoldase ClpX
by: Ling, Lorraine, Ph. D. Massachusetts Institute of Technology
Published: (2015) -
Hinge-Linker Elements in the AAA+ Protein Unfoldase ClpX Mediate Intersubunit Communication, Assembly, and Mechanical Activity
by: Bell, Tristan Andrew, et al.
Published: (2020) -
Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase
by: Schmitz, Karl Robert, et al.
Published: (2017) -
Auto-tethering as a selection mechanism for recognition of multimeric substrates by the AAA+ unfoldase ClpX
by: Abdelhakim, Aliaa H. (Aliaa Hamid)
Published: (2014) -
The AAA+ ClpX machine unfolds a keystone subunit to remodel the Mu transpososome
by: Baker, Tania, et al.
Published: (2011)