DNA sense-and-respond protein modules for mammalian cells
We generated synthetic protein components that can detect specific DNA sequences and subsequently trigger a desired intracellular response. These modular sensors exploit the programmability of zinc-finger DNA recognition to drive the intein-mediated splicing of an artificial trans-activator that sig...
Main Authors: | Slomovic, Shimyn (Contributor), Collins, James J. (Contributor) |
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Other Authors: | Institute for Medical Engineering and Science (Contributor), Collins, James (Contributor) |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2017-04-28T18:28:28Z.
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Subjects: | |
Online Access: | Get fulltext |
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