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|a dc
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|a Mathew, Rebecca S
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|a Institute for Medical Engineering and Science
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|a Harvard University-
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|a Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
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|a Picower Institute for Learning and Memory
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|a Rudenko, Andrii
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|a Martorell, Anthony
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|a Tsai, Li-Huei
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|a Yang, Yawei
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|a Tatarakis, Antonis
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|a Johnson-Venkatesh, Erin M
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|a Murphy, Elisabeth A
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|a Todd, Travis P
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|a Schepers, Scott T
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|a Siuti, Nertila
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|a Falls, William A
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|a Hammack, Sayamwong E
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|a Walsh, Christopher A
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|a Umemori, Hisashi
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|a Bouton, Mark E
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|a Moazed, Danesh
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|a Rudenko, Andrii
|e author
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|a Martorell, Anthony
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|a Tsai, Li-Huei
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|a Yang, Yawei
|e author
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|a A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory
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|b eLife Sciences Publications, Ltd.,
|c 2017-05-02T13:46:10Z.
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|z Get fulltext
|u http://hdl.handle.net/1721.1/108566
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|a The SNARE-mediated vesicular transport pathway plays major roles in synaptic remodeling associated with formation of long-term memories, but the mechanisms that regulate this pathway during memory acquisition are not fully understood. Here we identify miRNAs that are up-regulated in the rodent hippocampus upon contextual fear-conditioning and identify the vesicular transport and synaptogenesis pathways as the major targets of the fear-induced miRNAs. We demonstrate that miR-153, a member of this group, inhibits the expression of key components of the vesicular transport machinery, and down-regulates Glutamate receptor A1 trafficking and neurotransmitter release. MiR-153 expression is specifically induced during LTP induction in hippocampal slices and its knockdown in the hippocampus of adult mice results in enhanced fear memory. Our results suggest that miR-153, and possibly other fear-induced miRNAs, act as components of a negative feedback loop that blocks neuronal hyperactivity at least partly through the inhibition of the vesicular transport pathway.
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|a Brain & Behavior Research Foundation (Young Investigator Award)
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|a JPB Foundation
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|a en_US
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|a Article
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|t eLife
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