Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

Renal angiomyolipoma is a kidney tumor in the perivascular epithelioid (PEComa) family that is common in patients with Tuberous Sclerosis Complex (TSC) and Lymphangioleiomyomatosis (LAM) but occurs rarely sporadically. Though histologically benign, renal angiomyolipoma can cause life-threatening hem...

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Main Authors: Giannikou, Krinio (Author), Malinowska, Izabela A. (Author), Pugh, Trevor J. (Author), Yan, Rachel (Author), Tseng, Yuen-Yi (Author), Kim, Jaegil (Author), Tyburczy, Magdalena E. (Author), Chekaluk, Yvonne (Author), Liu, Yang (Author), Alesi, Nicola (Author), Finlay, Geraldine A. (Author), Wu, Chin-Lee (Author), Signoretti, Sabina (Author), Henske, Elizabeth P. (Author), Kwiatkowski, David J. (Author), Oh, Coyin (Contributor), Meyerson, Matthew L (Contributor), Getz, Gad Asher (Contributor), Boehm, Jesse S (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2017-05-10T18:33:18Z.
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