Confined crystallization of fenofibrate in nanoporous silica

Producing stable nanocrystals confined to porous excipient media is a desirable way to increase the dissolution rate and improve the bioavailability of poorly water soluble pharmaceuticals. The poorly soluble pharmaceutical fenofibrate was crystallized in controlled pore glass (CPG) of 10 different...

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Bibliographic Details
Main Authors: Dwyer, Leia Mary (Contributor), Michaelis, Vladimir K. (Contributor), O'Mahony, Marcus (Contributor), Griffin, Robert Guy (Contributor), Myerson, Allan S. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry, 2017-05-22T20:34:12Z.
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Online Access:Get fulltext
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042 |a dc 
100 1 0 |a Dwyer, Leia Mary  |e author 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemical Engineering  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Chemistry  |e contributor 
100 1 0 |a Francis Bitter Magnet Laboratory   |q  (Massachusetts Institute of Technology)   |e contributor 
100 1 0 |a Dwyer, Leia Mary  |e contributor 
100 1 0 |a Michaelis, Vladimir K.  |e contributor 
100 1 0 |a O'Mahony, Marcus  |e contributor 
100 1 0 |a Griffin, Robert Guy  |e contributor 
100 1 0 |a Myerson, Allan S.  |e contributor 
700 1 0 |a Michaelis, Vladimir K.  |e author 
700 1 0 |a O'Mahony, Marcus  |e author 
700 1 0 |a Griffin, Robert Guy  |e author 
700 1 0 |a Myerson, Allan S.  |e author 
245 0 0 |a Confined crystallization of fenofibrate in nanoporous silica 
260 |b Royal Society of Chemistry,   |c 2017-05-22T20:34:12Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/109274 
520 |a Producing stable nanocrystals confined to porous excipient media is a desirable way to increase the dissolution rate and improve the bioavailability of poorly water soluble pharmaceuticals. The poorly soluble pharmaceutical fenofibrate was crystallized in controlled pore glass (CPG) of 10 different pore sizes between 12 nm and 300 nm. High drug loadings of greater than 20 wt% were achieved across all pore sizes greater than 20 nm. Nanocrystalline fenofibrate was formed in pore sizes greater than 20 nm and showed characteristic melting point depressions following a Gibbs-Thomson relationship as well as enhanced dissolution rates. Solid-state Nuclear Magnetic Resonance (NMR) was employed to characterize the crystallinity of the confined molecules. These results help to advance the fundamental understanding of nanocrystallization in confined pores. 
520 |a Novartis-MIT Center for Continuous Manufacturing 
520 |a National Institute for Biomedical Imaging and Bioengineering (U.S.) (Grant EB-002026) 
520 |a Natural Sciences and Engineering Research Council of Canada (Banting Postdoctoral Fellowship) 
546 |a en_US 
655 7 |a Article 
773 |t CrystEngComm