Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers

Although it has become increasingly clear that cancers display extensive cellular heterogeneity, the spatial growth dynamics of genetically distinct clones within developing solid tumours remain poorly understood. Here we leverage mosaic analysis with double markers (MADM) to trace subclonal populat...

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Main Authors: Dorans, Kimberly (Contributor), Chung, Katherine Minjee (Contributor), Robbins, Rebecca (Contributor), Tammela, Tuomas (Contributor), Gocheva, Vasilena (Contributor), Jacks, Tyler E. (Contributor), Li, Carman Man Chung (Contributor), Muzumdar, Mandar (Contributor)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-05-26T17:24:43Z.
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