The complementary roles of dynamic contrast-enhanced MRI and [supersript 18]F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis

• Main Authors: Calcagno, Claudia (Author), Ramachandran, Sarayu (Author), Mani, Venkatesh (Author), Millon, Antoine (Author), Rosenbaum, David (Author), Tawakol, Ahmed (Author), Woodward, Mark (Author), Bucerius, Jan (Author), Moshier, Erin (Author), Godbold, James (Author), Kallend, David (Author), Farkouh, Michael E (Author), Fuster, Valentin (Author), Rudd, James H F (Author), Fayad, Zahi A (Author), Farkouh, Michael E. (Author), Rudd, James H. F. (Author), Fayad, Zahi A. (Author), Izquierdo-Garcia, David (Contributor)
• Other Authors: Martinos Imaging Center (McGovern Institute for Brain Research at MIT) (Contributor)
• Format: Article
• Language: English
• Published: Springer Berlin Heidelberg, 2017-05-31T13:37:18Z.
• Subjects: Article
• Online Access: Get fulltext

 Inflammation and neovascularization in vulnerable atherosclerotic plaques are key features for severe clinical events. Dynamic contrast-enhanced (DCE) MRI and FDG PET are two noninvasive imaging techniques capable of quantifying plaque neovascularization and inflammatory infiltrate, respectively. However, their mutual role in defining plaque vulnerability and their possible overlap has not been thoroughly investigated. We studied the relationship between DCE-MRI and [supersript 18]F-FDG PET data from the carotid arteries of 40 subjects with coronary heart disease (CHD) or CHD risk equivalent, as a substudy of the dal-PLAQUE trial (NCT00655473).