Materials for Diabetes Therapeutics

• Main Authors: Bratlie, Kaitlin M (Contributor), York, Roger L. (Contributor), Invernale, Michael A. (Contributor), Langer, Robert S (Contributor), Anderson, Daniel Griffith (Contributor)
• Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
• Format: Article
• Language: English
• Published: Wiley Blackwell, 2017-05-31T15:24:25Z.
• Subjects: Article
• Online Access: Get fulltext

This review is focused on the materials and methods used to fabricate closed-loop systems for type 1 diabetes therapy. Herein, we give a brief overview of current methods used for patient care and discuss two types of possible treatments and the materials used for these therapies-(i) artificial pancreases, comprised of insulin producing cells embedded in a polymeric biomaterial, and (ii) totally synthetic pancreases formulated by integrating continuous glucose monitors with controlled insulin release through degradable polymers and glucose-responsive polymer systems. Both the artificial and the completely synthetic pancreas have two major design requirements: the device must be both biocompatible and be permeable to small molecules and proteins, such as insulin. Several polymers and fabrication methods of artificial pancreases are discussed: microencapsulation, conformal coatings, and planar sheets. We also review the two components of a completely synthetic pancreas. Several types of glucose sensing systems (including materials used for electrochemical, optical, and chemical sensing platforms) are discussed, in addition to various polymer-based release systems (including ethylene-vinyl acetate, polyanhydrides, and phenylboronic acid containing hydrogels).
Juvenile Diabetes Research Foundation International (17-2007-1063)
Leona M. and Harry B. Helmsley Charitable Trust (09PG-T1D027)
United States. National Institutes of Health (F32 EB011580-01)