Controversy in statistical analysis of functional magnetic resonance imaging data

To test the validity of statistical methods for fMRI data analysis, Eklund et al. (1) used, for the first time, large-scale experimental data rather than simulated data. Using resting-state fMRI measurements to represent a null hypothesis of no task-induced activation, the authors compare familywise...

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Bibliographic Details
Main Authors: Behrmann, Marlene (Author), Brown, Emery Neal (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: National Academy of Sciences (U.S.), 2017-11-02T19:00:09Z.
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Online Access:Get fulltext
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100 1 0 |a Behrmann, Marlene  |e author 
100 1 0 |a Massachusetts Institute of Technology. Institute for Medical Engineering & Science  |e contributor 
100 1 0 |a Harvard University-  |e contributor 
100 1 0 |a Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences  |e contributor 
100 1 0 |a Brown, Emery Neal  |e contributor 
700 1 0 |a Brown, Emery Neal  |e author 
245 0 0 |a Controversy in statistical analysis of functional magnetic resonance imaging data 
260 |b National Academy of Sciences (U.S.),   |c 2017-11-02T19:00:09Z. 
856 |z Get fulltext  |u http://hdl.handle.net/1721.1/112127 
520 |a To test the validity of statistical methods for fMRI data analysis, Eklund et al. (1) used, for the first time, large-scale experimental data rather than simulated data. Using resting-state fMRI measurements to represent a null hypothesis of no task-induced activation, the authors compare familywise error rates for voxel-based and cluster-based inferences for both parametric and nonparametric methods. Eklund et al.'s study used three fMRI statistical analysis packages. They found that, for a target familywise error rate of 5%, the parametric methods gave invalid cluster-based inferences and conservative voxel-based inferences. 
655 7 |a Article 
773 |t Proceedings of the National Academy of Sciences